Genetic and epigenetic stability of stem cells: Epigenetic modifiers modulate the fate of mesenchymal stem cells.
Epigenetic instability
Epigenetic modifiers
Genetic instability
Stem cells
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
13
12
2019
revised:
08
04
2020
accepted:
24
04
2020
pubmed:
1
5
2020
medline:
7
10
2021
entrez:
1
5
2020
Statut:
ppublish
Résumé
Stem cell research has progressed widely and has been receiving a considerable attention for its advantages and drawbacks. Despite their extensive therapeutic potential in regenerative medicine, they are debatable for their genetic and epigenetic stability. In fact lineage specific differentiation is mediated via epigenetic changes in DNA methylation, acetylation, histone modifications etc. Thus epigenetics plays an important role in stem cell biology. For therapeutic interventions stem cells need to be genetically and epigenetically stable for their maximum paracrine secretions for bringing about expected tissue repair and regeneration. In this review we have focused on the current status of genetic and epigenetic stability in stem cells and their importance in regenerative medicine. We have also touched upon the possibility of considering tissue resident mesenchymal stem cells as epigenetic modifiers. This is likely to open a new era in stem cell therapeutic intervention by reversing disease inducing epigenetic changes.
Identifiants
pubmed: 32353479
pii: S0888-7543(19)31011-0
doi: 10.1016/j.ygeno.2020.04.022
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3615-3623Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.