FALC stromal cells define a unique immunological niche for the surveillance of serous cavities.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
14
10
2019
revised:
04
03
2020
accepted:
10
03
2020
pubmed:
1
5
2020
medline:
5
4
2022
entrez:
1
5
2020
Statut:
ppublish
Résumé
The serous cavities contain specialised adipose tissues which house small clusters of immune cells known as fat-associated lymphoid clusters (FALCs). The continuous flow of fluid from the serous cavities through FALCs makes them unique niches for the clearance of fluid phase contaminants and initiation of locally protective immune responses during infection and inflammation. Development, and activation of FALCs both at homeostasis and following inflammation are co-ordinated by the close interaction of mesothelial and fibroblastic stromal cell populations with immune cells. In this review we discuss recent developments in FALC stromal cell biology and highlight key interactions that occur between FALC stroma and immune cells.
Identifiants
pubmed: 32353646
pii: S0952-7915(20)30031-5
doi: 10.1016/j.coi.2020.03.008
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-49Subventions
Organisme : Medical Research Council
ID : MR/M011542/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 213697/Z/18/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.