The Spindle Assembly Checkpoint Functions during Early Development in Non-Chordate Embryos.
Animals
Cell Cycle Checkpoints
/ physiology
Cell Cycle Proteins
/ metabolism
Chromosome Segregation
/ physiology
Embryo, Nonmammalian
/ metabolism
Invertebrates
/ embryology
Kinetochores
/ metabolism
M Phase Cell Cycle Checkpoints
/ physiology
Microtubules
/ metabolism
Mitosis
/ physiology
Nocodazole
/ pharmacology
Signal Transduction
/ physiology
Spindle Apparatus
/ metabolism
chordates
embryo
mitosis
spindle checkpoint
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 04 2020
28 04 2020
Historique:
received:
24
03
2020
revised:
22
04
2020
accepted:
24
04
2020
entrez:
2
5
2020
pubmed:
2
5
2020
medline:
4
3
2021
Statut:
epublish
Résumé
In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation, by monitoring proper attachment of chromosomes to spindle microtubules and delaying mitotic progression if connections are erroneous or absent. The SAC is thought to be relaxed during early embryonic development. Here, we evaluate the checkpoint response to lack of kinetochore-spindle microtubule interactions in early embryos of diverse animal species. Our analysis shows that there are two classes of embryos, either proficient or deficient for SAC activation during cleavage. Sea urchins, mussels, and jellyfish embryos show a prolonged delay in mitotic progression in the absence of spindle microtubules from the first cleavage division, while ascidian and amphioxus embryos, like those of
Identifiants
pubmed: 32354040
pii: cells9051087
doi: 10.3390/cells9051087
pmc: PMC7290841
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
Nocodazole
SH1WY3R615
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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