Development of a Disposable Single-Nozzle Printhead for 3D Bioprinting of Continuous Multi-Material Constructs.
3D bioprinting
continuous multi-material printing
multi-material printing
single-nozzle printing
Journal
Micromachines
ISSN: 2072-666X
Titre abrégé: Micromachines (Basel)
Pays: Switzerland
ID NLM: 101640903
Informations de publication
Date de publication:
28 Apr 2020
28 Apr 2020
Historique:
received:
15
04
2020
revised:
27
04
2020
accepted:
27
04
2020
entrez:
2
5
2020
pubmed:
2
5
2020
medline:
2
5
2020
Statut:
epublish
Résumé
Fabricating multi-cell constructs in complex geometries is essential in the field of tissue engineering, and three-dimensional (3D) bioprinting is widely used for this purpose. To enhance the biological and mechanical integrity of the printed constructs, continuous single-nozzle printing is required. In this paper, a novel single-nozzle printhead for 3D bioprinting of multi-material constructs was developed and characterized. The single-nozzle multi-material bioprinting was achieved via a disposable, inexpensive, multi-fuse IV extension set; the printhead can print up to four different biomaterials. The transition distance of the developed printhead was characterized over a range of pressures and needle inner diameters. Finally, the transition distance was decreased by applying a silicon coating to the inner channels of the printhead.
Identifiants
pubmed: 32354128
pii: mi11050459
doi: 10.3390/mi11050459
pmc: PMC7281083
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 537244-2018
Organisme : Canada Foundation for Innovation
ID : 37696
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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