Neural Stem Cell Transplantation for Neurodegenerative Diseases.
cell therapy
neural subpopulation
neurodegenerative disease
neuronal stem cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Apr 2020
28 Apr 2020
Historique:
received:
30
03
2020
revised:
24
04
2020
accepted:
27
04
2020
entrez:
2
5
2020
pubmed:
2
5
2020
medline:
3
2
2021
Statut:
epublish
Résumé
Neurodegenerative diseases are disabling and fatal neurological disorders that currently lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a potential therapeutic approach and appears to exert a beneficial effect against neurodegeneration via different mechanisms, such as the production of neurotrophic factors, decreased neuroinflammation, enhanced neuronal plasticity and cell replacement. Thus, NSC transplantation may represent an effective therapeutic strategy. To exploit NSCs' potential, some of their essential biological characteristics must be thoroughly investigated, including the specific markers for NSC subpopulations, to allow profiling and selection. Another key feature is their secretome, which is responsible for the regulation of intercellular communication, neuroprotection, and immunomodulation. In addition, NSCs must properly migrate into the central nervous system (CNS) and integrate into host neuronal circuits, enhancing neuroplasticity. Understanding and modulating these aspects can allow us to further exploit the therapeutic potential of NSCs. Recent progress in gene editing and cellular engineering techniques has opened up the possibility of modifying NSCs to express select candidate molecules to further enhance their therapeutic effects. This review summarizes current knowledge regarding these aspects, promoting the development of stem cell therapies that could be applied safely and effectively in clinical settings.
Identifiants
pubmed: 32354178
pii: ijms21093103
doi: 10.3390/ijms21093103
pmc: PMC7247151
pii:
doi:
Substances chimiques
Nerve Growth Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Health
ID : RF-2016-02362317
Organisme : Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
ID : Ricerca Corrente 2019
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