A typical antipsychotic treatment induced gradually expanding white matter alterations in healthy individuals with persistent auditory verbal hallucinations-an artificially controlled pilot study.
Adult
Antipsychotic Agents
/ administration & dosage
Corpus Callosum
/ diagnostic imaging
Diffusion Tensor Imaging
Female
Hallucinations
/ diagnostic imaging
Humans
Male
Neural Pathways
/ diagnostic imaging
Outcome Assessment, Health Care
Pilot Projects
Risperidone
/ administration & dosage
White Matter
/ diagnostic imaging
Young Adult
Atypical antipsychotics
TBSS
auditory verbal hallucinations
white matter
Journal
The International journal of neuroscience
ISSN: 1563-5279
Titre abrégé: Int J Neurosci
Pays: England
ID NLM: 0270707
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
2
5
2020
medline:
18
11
2021
entrez:
2
5
2020
Statut:
ppublish
Résumé
The aim of this study was to explore the effects of atypical antipsychotics (AaPs) on brain white matter (WM) tracts in healthy individuals with auditory verbal hallucinations (Hi-AVHs). We analyzed neuroimaging, AVH symptoms, and cognitive assessment data obtained from 39 Hi-AVHs who reported being distressed by persistent AVHs and volunteered to receive AaP treatment. We used tract-based spatial statistics (TBSS) and TBSS and The worsening of AaP-associated WM alterations observed in this study suggest that AaPs may not be a good choice for the treatment of Hi-AVHs despite their ability to alleviate AVHs.
Identifiants
pubmed: 32354294
doi: 10.1080/00207454.2020.1750387
doi:
Substances chimiques
Antipsychotic Agents
0
Risperidone
L6UH7ZF8HC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM