Serum myostatin levels are positively associated with diabetic retinopathy in individuals with type 2 diabetes mellitus.

Cross-Sectional Studies Diabetes Mellitus, Type 2 / complications Diabetic Retinopathy / blood Humans Logistic Models Myostatin / blood
Diabetes mellitus, type 2 Diabetic retinopathy Myostatin

Journal

Journal of diabetes and its complications
ISSN: 1873-460X
Titre abrégé: J Diabetes Complications
Pays: United States
ID NLM: 9204583

Informations de publication

Date de publication:
07 2020
Historique:
received: 27 02 2020
revised: 14 04 2020
accepted: 14 04 2020
pubmed: 2 5 2020
medline: 24 11 2021
entrez: 2 5 2020
Statut: ppublish

Résumé

To examine the relationship between serum myostatin levels and diabetic retinopathy in individuals with type 2 diabetes mellitus (DM). This cross-sectional study evaluated 246 individuals with type 2 DM. Analysis of covariance was performed after adjusting for confounders. A logistic regression model was used to evaluate the relationship between serum myostatin levels and diabetic retinopathy. Serum myostatin levels were significantly higher in individuals with diabetic retinopathy than in those without. After adjusting for other covariates, the mean serum myostatin levels were significantly different according to the severity of retinopathy (without diabetic retinopathy, 2234 pg/mL; non-proliferative diabetic retinopathy, 2698 pg/mL; and proliferative diabetic retinopathy, 3076 pg/mL; p for trend = 0.004). The multivariate analysis showed that serum myostatin levels were significantly associated with diabetic retinopathy (odds ratio for every 1 standard deviation-increase in logarithmic value, 1.77; 95% confidence interval: 1.21-2.59; p = 0.003). Serum myostatin levels were positively associated with diabetic retinopathy in individuals with type 2 DM.

Identifiants

DOI: 10.1016/j.jdiacomp.2020.107592 PMID: 32354624
pubmed: 32354624
pii: S1056-8727(20)30344-5
doi: 10.1016/j.jdiacomp.2020.107592
pii:
doi:

Substances chimiques

Myostatin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

107592

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Jin Ook Chung (JO)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju 501-757, Republic of Korea.

Seon-Young Park (SY)

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju 501-757, Republic of Korea. Electronic address: drpsy@naver.com.

Dong Jin Chung (DJ)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju 501-757, Republic of Korea.

Min Young Chung (MY)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju 501-757, Republic of Korea. Electronic address: jrjjo222@gmail.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Serum myostatin levels are positively...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Serum myostatin levels are positively...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Angiopathies diabétiques › Rétinopathie diabétique › Serum myostatin levels are positively...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Serum myostatin levels are positively...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles logistiques › Serum myostatin levels are positively...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteurs de croissance et de différenciation › Myostatine › Serum myostatin levels are positively...