Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates.
calcium and bone
fluid electrolyte and acid-base disturbances
vitamins and supplements
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
29 Apr 2020
29 Apr 2020
Historique:
entrez:
2
5
2020
pubmed:
2
5
2020
medline:
12
1
2021
Statut:
epublish
Résumé
Hypercalcaemia is a common diagnosis with the majority of cases resulting from hyperparathyroidism or malignancy. We report a rare case of persistent symptomatic hypervitaminosis D-induced hypercalcaemia in an individual taking 50 000 IU of vitamin D supplement daily for several months following a diagnosis of vitamin D deficiency. His hypercalcaemia was initially treated with calcitonin and intravenous fluids, but due to recurrent symptomatic hypercalcaemia after discharge, additional treatment with glucocorticoids and bisphosphonates was warranted during his second admission. The pathophysiology of hypercalcaemia from vitamin D intoxication results from the long-term effects of vitamin D storage in adipose tissue. In the present case, we discuss this pathophysiology and treatment approaches in the context of increasing awareness of and testing for vitamin D deficiency, and growing access to over-the-counter supplements.
Identifiants
pubmed: 32354763
pii: 13/4/e233853
doi: 10.1136/bcr-2019-233853
pmc: PMC7213704
pii:
doi:
Substances chimiques
Vitamin D
1406-16-2
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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