Long-term outcomes following a diagnosis of ovarian cancer at the time of preventive oophorectomy among


Journal

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
ISSN: 1525-1438
Titre abrégé: Int J Gynecol Cancer
Pays: England
ID NLM: 9111626

Informations de publication

Date de publication:
06 2020
Historique:
received: 10 12 2019
revised: 24 01 2020
accepted: 05 03 2020
pubmed: 2 5 2020
medline: 16 6 2021
entrez: 2 5 2020
Statut: ppublish

Résumé

Preventive bilateral salpingo-oophorectomy is the most effective means of reducing the risk of ovarian cancer among women with an inherited We estimated the 10-year survival for 52 The mean age at diagnosis was 51.6 (range 33-69) years. All were serous cancers (although 14 were missing information on histologic subtype). Of the 20 cases with information available on stage at diagnosis, 10 were stage I, 1 was stage II, and 9 were stage III (n=32 missing). After a mean of 6.8 years, 12 women died (23%). The 10-year all-cause survival was 74%. Although based on only 52 cases, these findings suggest a more favorable prognosis for

Identifiants

pubmed: 32354794
pii: ijgc-2019-001141
doi: 10.1136/ijgc-2019-001141
doi:

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

825-830

Informations de copyright

© IGCS and ESGO 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Joanne Kotsopoulos (J)

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Beth Karlan (B)

David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

Jacek Gronwald (J)

International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian, Pomeranian Medical University in Szczecin, Szczecin, Zachodniopomorskie, Poland.

Elizabeth Hall (E)

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.

Pal Moller (P)

Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Nadine Tung (N)

Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Dana Zakalik (D)

Beaumont Hospital, Royal Oak, Troy, Michigan, USA.

William D Foulkes (WD)

Program in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada.

Barry Rosen (B)

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.

Susan L Neuhausen (SL)

Division of Biomarkers of Early Detection and Prevention, Department of Population Sciences, Beckman Research Institute City of Hope, Duarte, California, USA.

Ping Sun (P)

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.

Jan Lubinksi (J)

International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian, Pomeranian Medical University in Szczecin, Szczecin, Zachodniopomorskie, Poland.

Steven A Narod (SA)

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada steven.narod@wchospital.ca.
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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