Salvage Re-irradiation Options in Adult Medulloblastoma: A Case Report and Review of the Literature.
Medulloblastoma
adult patients
re-irradiation
Journal
In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809
Informations de publication
Date de publication:
Historique:
received:
02
01
2020
revised:
25
01
2020
accepted:
29
01
2020
entrez:
2
5
2020
pubmed:
2
5
2020
medline:
13
2
2021
Statut:
ppublish
Résumé
Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage re-irradiation collecting very heterogeneous series. A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease. Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage re-irradiation collecting very heterogeneous series.
CASE REPORT
METHODS
A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease.
CONCLUSION
CONCLUSIONS
Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.
Identifiants
pubmed: 32354920
pii: 34/3/1283
doi: 10.21873/invivo.11903
pmc: PMC7279819
doi:
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1283-1288Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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