Interferon Alfa-2b for Pigmented Ocular Surface Squamous Neoplasia: A Report of 8 Lesions.
Administration, Ophthalmic
Aged
Aged, 80 and over
Antineoplastic Agents
/ therapeutic use
Carcinoma, Squamous Cell
/ drug therapy
Conjunctival Neoplasms
/ drug therapy
Corneal Diseases
/ drug therapy
Eye Neoplasms
/ drug therapy
Female
Follow-Up Studies
Humans
Injections, Intraocular
Interferon alpha-2
/ therapeutic use
Limbus Corneae
/ drug effects
Male
Melanosis
/ pathology
Middle Aged
Ophthalmic Solutions
Retrospective Studies
Treatment Outcome
Journal
Cornea
ISSN: 1536-4798
Titre abrégé: Cornea
Pays: United States
ID NLM: 8216186
Informations de publication
Date de publication:
01 Feb 2021
01 Feb 2021
Historique:
received:
20
02
2020
accepted:
11
03
2020
pubmed:
2
5
2020
medline:
13
8
2021
entrez:
2
5
2020
Statut:
ppublish
Résumé
To study the efficacy of interferon alfa-2b (IFN-a2b) on pigmented ocular surface squamous neoplasia (p-OSSN) and assess the resolution of the pigment to the treatment. A retrospective case series of 8 tumors in 7 patients. The mean age at diagnosis of p-OSSN was 65 years (median, 61 years; range, 51-84 years), and all patients were men. The mean duration of symptoms was 2 months (median, 1 month; range, 1-4 months). One patient had 2 distinct lesions in the same eye. Tumor epicenter was located at the limbus (n = 5) or bulbar conjunctiva (n = 2). Complexion-associated melanosis was noted in all eyes. The mean basal dimension of the tumor was 8 mm (median, 7 mm; range, 5-12 mm). The mean % of tumor pigmentation was 47% (median, 30%; range, 10%-100%). The treatment details included topical IFN-a2b (n = 1) or a combination of topical and subconjunctival injection of IFN-a2b (n = 7). All patients with p-OSSN showed excellent response to IFN-a2b with complete tumor regression and resolution of tumor-associated pigment with a mean number of 2 subconjunctival IFN-a2b injections (median, 2; range, 0-3) and topical IFN-a2b for an average of 2 months (median, 2 months; range, 1-3 months). There was no change in the complexion-associated melanosis with IFN-a2b. IFN-a2b is very effective in the management of p-OSSN. There is a complete resolution of the pigment along with the tumor.
Identifiants
pubmed: 32355112
pii: 00003226-202102000-00002
doi: 10.1097/ICO.0000000000002350
doi:
Substances chimiques
Antineoplastic Agents
0
Interferon alpha-2
0
Ophthalmic Solutions
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
142-146Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
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