pSTAT3 Y705 is a prognostic biomarker identified from time-series gene expression profiles of a chemically induced mouse model of hepatocellular carcinoma.
Hepatocellular carcinoma
gene expression profiles
mouse models
pSTAT3 Y705
prognostic biomarkers
Journal
American journal of translational research
ISSN: 1943-8141
Titre abrégé: Am J Transl Res
Pays: United States
ID NLM: 101493030
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
08
2019
accepted:
03
04
2020
entrez:
2
5
2020
pubmed:
2
5
2020
medline:
2
5
2020
Statut:
epublish
Résumé
Development of hepatocellular carcinoma (HCC) is a dynamic process that includes a spectrum ranging from precancerous exposure to carcinogenesis and metastasis stages. In this process, numerous dysregulated genes resulted in aberrant activation or inhibition of signaling pathways. Herein, time-series gene expression profiles of dimethylnitrosamine (DEN)-induced mice with HCC covering different stages are provided. Gene expression patterns of liver tissues were detected at different time intervals [0 (negative control; NC), 15, 28, 30, and 42 weeks]. A comparison of gene expression between DEN-treated groups and NC yielded a total of 726 differentially expressed genes (DEGs), 76 of which were enriched in 10 statistically significant Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways (adjusted
Types de publication
Journal Article
Langues
eng
Pagination
1443-1458Informations de copyright
AJTR Copyright © 2020.
Déclaration de conflit d'intérêts
None.
Références
Mol Cell Biol. 1997 Sep;17(9):5307-16
pubmed: 9271408
Bioinformatics. 2015 Oct 15;31(20):3359-61
pubmed: 26069263
Cancer Res. 1993 Feb 15;53(4):790-4
pubmed: 8381328
Pharmacol Ther. 1996;71(1-2):57-81
pubmed: 8910949
Adv Pharmacol. 2015;74:223-62
pubmed: 26233909
Nucleic Acids Res. 2019 Jan 8;47(D1):D33-D38
pubmed: 30204897
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Hepatology. 2015 Oct;62(4):1160-73
pubmed: 26154152
Mol Cell Biol. 1997 Nov;17(11):6508-16
pubmed: 9343414
Cell Res. 2011 Jan;21(1):159-68
pubmed: 21187858
J Hepatol. 2019 May;70(5):904-917
pubmed: 30654066
BMC Syst Biol. 2016 Sep 06;10(1):88
pubmed: 27599550
J Hepatol. 2018 Oct;69(4):840-850
pubmed: 29958939
Cell. 1995 Jul 28;82(2):241-50
pubmed: 7543024
Mol Carcinog. 2014 Jan;53(1):67-76
pubmed: 22911886
Nat Genet. 2004 Dec;36(12):1306-11
pubmed: 15565109
Arch Toxicol. 2013 Feb;87(2):227-47
pubmed: 23007558
Blood. 2001 Dec 15;98(13):3853-6
pubmed: 11739197
Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17779-84
pubmed: 22006329
Nat Rev Immunol. 2015 Aug;15(8):511-23
pubmed: 26139350
Free Radic Biol Med. 2002 May 1;32(9):822-32
pubmed: 11978484
Nat Commun. 2018 Feb 14;9(1):678
pubmed: 29445139
Front Immunol. 2018 Jan 29;9:38
pubmed: 29434586
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Clin Cancer Res. 2016 Feb 1;22(3):691-703
pubmed: 26405196
Chem Biol Interact. 2006 Mar 10;160(1):1-40
pubmed: 16430879
J Hepatol. 2009 Oct;51(4):810-20
pubmed: 19545926
Viruses. 2013 Jan 28;5(2):439-69
pubmed: 23358390
Cytokine. 2019 Jun;118:27-34
pubmed: 30031681
Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):160-174
pubmed: 30518830
Nat Rev Cancer. 2002 Aug;2(8):563-72
pubmed: 12154349
Oncotarget. 2015 Sep 15;6(27):23306-22
pubmed: 26259234
J Hepatol. 2018 Mar;68(3):526-549
pubmed: 28989095
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Cancer Res. 1985 Feb;45(2):909-12
pubmed: 3967250
Nat Rev Dis Primers. 2016 Apr 14;2:16018
pubmed: 27158749