The role of innate immunity in the long-term outcome of lung transplantation.
Immunity
fibrosis
graft rejection
innate
lung transplantation
Journal
Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
2
5
2020
pubmed:
2
5
2020
medline:
2
5
2020
Statut:
ppublish
Résumé
Long-term survival after lung transplantation remains suboptimal due to chronic lung allograft dysfunction (CLAD), a progressive scarring process affecting the graft. Although anti-donor alloimmunity is central to the pathogenesis of CLAD, its underlying mechanisms are not fully elucidated and it is neither preventable nor treatable using currently available immunosuppression. Recent evidence has shown that innate immune stimuli are fundamental to the development of CLAD. Here, we examine long-standing assumptions and new concepts linking innate immune activation to late lung allograft fibrosis.
Identifiants
pubmed: 32355856
doi: 10.21037/atm.2020.03.20
pii: atm-08-06-412
pmc: PMC7186608
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
412Informations de copyright
2020 Annals of Translational Medicine. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: The series “Strategies to Achieve Long-Term Success of Lung Transplantation” was commissioned by the editorial office without any funding or sponsorship. SJ has grant support from the Ontario Thoracic Society Grant-in-Aid, the Caron Thorburn Foundation and from the US Cystic Fibrosis Foundation. SJ has received research grant support from Sanofi. The other authors have no other conflicts of interest to declare.
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