Photothermal augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode.
Adenocarcinoma
/ drug therapy
Albumin-Bound Paclitaxel
/ administration & dosage
Animals
Antineoplastic Agents
/ administration & dosage
Cancer-Associated Fibroblasts
/ drug effects
Cell Line, Tumor
Cell Survival
/ drug effects
Erythrocytes
/ drug effects
Hemolysis
/ drug effects
Humans
Lasers
Mice, Nude
Molybdenum
/ administration & dosage
Pancreatic Neoplasms
/ drug therapy
Photochemotherapy
Selenium
/ administration & dosage
Journal
Biomaterials science
ISSN: 2047-4849
Titre abrégé: Biomater Sci
Pays: England
ID NLM: 101593571
Informations de publication
Date de publication:
21 Jun 2020
21 Jun 2020
Historique:
pubmed:
2
5
2020
medline:
20
1
2021
entrez:
2
5
2020
Statut:
ppublish
Résumé
Cancer-associated fibroblasts (CAFs) are crucial for forming the desmoplastic stroma that is associated with chemoresistance in pancreatic ductal adenocarcinoma (PDAC). In the clinic, depleting dense stroma in PDAC tumor tissue is a promising chemotherapeutic strategy. In this study, we report that the local hyperthermia can reduce the number of CAFs in the PDAC PDX mouse mode, which further augments chemotherapeutic efficiency in the PDAC therapy. To achieve this goal, a photothermal-chemotherapeutic agent termed as Abraxane@MoSe
Substances chimiques
Albumin-Bound Paclitaxel
0
Antineoplastic Agents
0
Molybdenum
81AH48963U
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM