The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis: a proof-of-concept study.
Fluconazole
Lactobacilli
Prevention
Recurrent Candida vulvovaginitis
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
28
01
2020
accepted:
16
03
2020
pubmed:
2
5
2020
medline:
17
3
2021
entrez:
2
5
2020
Statut:
ppublish
Résumé
In vitro studies suggest that certain probiotic bacterial strains have potential activity against opportunistic infections such as Candida. There are few in vivo trials using probiotics as a single treatment for acute Candida vulvovaginitis (CV). In this open-label, proof-of-concept study, selected Lactobacillus strains were tested in women with acute Candida vaginitis. Twenty women diagnosed with proven, symptomatic CV were instructed to administer a vaginal probiotic gel with L. plantarum YUN-V2.0, L. pentosus YUN-V1.0 and L. rhamnosus YUN-S1.0 for 10 consecutive days. Vaginal rinsing fluid, vaginal culture swab and vaginal smear for fresh wet-mount microscopy were collected before and 7, 14 and 28 days after start of treatment. On average, participating women were 39 years old and had an history of 5 vaginal infections of which 95% was CV. Nine women (45%) completed the study without the need of rescue medication. Women who needed rescue treatment experienced twice as much Candida infections in the past. A negative correlation was found between the clinical composite score and the time to use rescue medication (R
Identifiants
pubmed: 32356027
doi: 10.1007/s10096-020-03868-x
pii: 10.1007/s10096-020-03868-x
doi:
Substances chimiques
Antifungal Agents
0
Vaginal Creams, Foams, and Jellies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1551-1558Références
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