A pharmacokinetic-pharmacodynamic real-time display may change anesthesiologists' behavior.
Anesthesiologist
Behavior
Pharmacodynamics
Pharmacokinetics
Simulation
Journal
Journal of clinical monitoring and computing
ISSN: 1573-2614
Titre abrégé: J Clin Monit Comput
Pays: Netherlands
ID NLM: 9806357
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
10
09
2019
accepted:
07
04
2020
pubmed:
2
5
2020
medline:
29
10
2021
entrez:
2
5
2020
Statut:
ppublish
Résumé
We have developed a real-time graphical display that presents anesthetic pharmacology data (drug effect site concentrations (Ce) and probability of anesthetic effects including hypnosis, loss of response to tracheal intubation), improving a previous prototype. We hypothesized that the use of the display alters (1) clinical behavior of anesthesiologists (i.e., Ce of isoflurane and fentanyl at the end of anesthesia), (2) fentanyl dose during the first 30 min of recovery in the post anesthesia care unit (PACU), and that the response of clinicians to the display in terms of workload and utility is favorable. The display was evaluated in a two-group, non-randomized prospective observational study of 30 patients undergoing general anesthesia using isoflurane and fentanyl. The isoflurane-predicted Ce was lower in the display group (without-display: 0.64% ± 0.06%; with-display: 0.42 ± 0.04%; t
Identifiants
pubmed: 32356076
doi: 10.1007/s10877-020-00510-1
pii: 10.1007/s10877-020-00510-1
doi:
Substances chimiques
Isoflurane
CYS9AKD70P
Fentanyl
UF599785JZ
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
547-556Références
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