Deciphering the Mechanism of the Anti-Hypertensive Effect of Isorhynchophylline by Targeting Neurotransmitters Metabolism of Hypothalamus in Spontaneously Hypertensive Rats.
Targeted metabolomics
angiotensin II
hypertension
hypothalamus
isorhynchophylline
neurotransmitter
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
03 06 2020
03 06 2020
Historique:
pubmed:
2
5
2020
medline:
22
6
2021
entrez:
2
5
2020
Statut:
ppublish
Résumé
Essential hypertension is a major risk factor for cardiovascular disease that can lead eventually to structural and functional alterations in the brain. Accumulating evidence has suggested that the increased activities in renin-angiotensin system and sympathetic nerve participated in the pathogenesis of hypertension that is related to the imbalance between neurotransmitters. The potential role in essential hypertension arising from alterations of neurotransmitters in the central nervous system remains understudied. Isorhynchophylline is a major oxindole alkaloid extracted from
Identifiants
pubmed: 32356970
doi: 10.1021/acschemneuro.9b00699
doi:
Substances chimiques
Antihypertensive Agents
0
Oxindoles
0
rhyncophylline
46BQ79VJ8D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM