Design, Synthesis, and Insecticidal Activity of Novel Doramectin Derivatives Containing Acylurea and Acylthiourea Based on Hydrogen Bonding.

Animals Insecticides / chemical synthesis Ivermectin / analogs & derivatives Larva / drug effects Molecular Structure Moths / drug effects Structure-Activity Relationship Thiourea / chemistry
acylthiourea acylurea corn borer diamondback moth insecticidal activities molecular docking oriental armyworm

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
27 May 2020
Historique:
pubmed: 2 5 2020
medline: 8 1 2021
entrez: 2 5 2020
Statut: ppublish

Résumé

Our recent investigation on the insecticidal activities of several doramectin derivatives preliminarily revealed that the presence of hydrogen bonds at the C4″ position of the molecule with target protein γ-aminobutyric acid (GABA) receptor was crucial for retaining high insecticidal activity. As a continuation of our research work on the development of new insecticides, two series of novel acylurea and acylthiourea doramectin derivatives were designed and synthesized. The bioassay results indicated that the newly synthesized compounds (

Identifiants

DOI: 10.1021/acs.jafc.0c00230 PMID: 32356977
pubmed: 32356977
doi: 10.1021/acs.jafc.0c00230
doi:

Substances chimiques

Insecticides 0
Ivermectin 70288-86-7
Thiourea GYV9AM2QAG
doramectin KGD7A54H5P

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5806-5815

Auteurs

Qi Zhang (Q)

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, People's Republic of China.
Department of Chemical and Chemical Engineering, Hefei Normal University, Hefei, Anhui 230601, People's Republic of China.

Yao Cheng (Y)

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, People's Republic of China.
University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

Cheng Zheng (C)

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, People's Republic of China.
University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

Ping Bai (P)

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, People's Republic of China.
University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

Jian Yang (J)

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, People's Republic of China.
University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

Xiaoxia Lu (X)

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, People's Republic of China.
University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
ORCID: 0000-0002-8559-7584

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Design, Synthesis, and Insecticidal Activity...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Insecticides › Design, Synthesis, and Insecticidal Activity...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Ivermectine › Design, Synthesis, and Insecticidal Activity...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Larve › Design, Synthesis, and Insecticidal Activity...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Design, Synthesis, and Insecticidal Activity...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Lepidoptera › Papillons de nuit › Design, Synthesis, and Insecticidal Activity...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design, Synthesis, and Insecticidal Activity...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiourée › Design, Synthesis, and Insecticidal Activity...