Reduced stiffness and augmented traction force in type 2 diabetic coronary microvascular smooth muscle.
Adult
Animals
Aorta
/ physiopathology
Coronary Vessels
/ physiopathology
Diabetes Mellitus, Type 2
/ physiopathology
Elastic Modulus
Female
Humans
Male
Mice
Microcirculation
/ physiology
Microscopy, Atomic Force
Middle Aged
Muscle, Smooth, Vascular
/ physiopathology
Myocytes, Smooth Muscle
/ physiology
atomic force microscopy
coronary microcirculation
diabetes
stiffness
traction force microscopy
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
pubmed:
2
5
2020
medline:
14
7
2020
entrez:
2
5
2020
Statut:
ppublish
Résumé
Type 2 diabetic (T2DM) coronary resistance microvessels (CRMs) undergo inward hypertrophic remodeling associated with reduced stiffness and reduced coronary blood flow in both mice and pig models. Since reduced stiffness does not appear to be due to functional changes in the extracellular matrix, this study tested the hypothesis that decreased CRM stiffness in T2DM is due to reduced vascular smooth muscle cell (VSMC) stiffness, which impacts the traction force generated by VSMCs. Atomic force microscopy (AFM) and traction force microscopy (TFM) were conducted on primary low-passage CRM VSMCs from normal
Identifiants
pubmed: 32357115
doi: 10.1152/ajpheart.00542.2019
pmc: PMC7311703
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
H1410-H1419Subventions
Organisme : NHLBI NIH HHS
ID : R00 HL116769
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB026518
Pays : United States
Organisme : NIH HHS
ID : S10 OD023438
Pays : United States
Organisme : ODCDC CDC HHS
ID : S10 OD023438
Pays : United States
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