Ghrelin ameliorates chronic obstructive pulmonary disease-associated infllammation and autophagy.
autophagy
cigarette extract
particle matter
Journal
Biotechnology and applied biochemistry
ISSN: 1470-8744
Titre abrégé: Biotechnol Appl Biochem
Pays: United States
ID NLM: 8609465
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
14
11
2019
accepted:
23
04
2020
pubmed:
2
5
2020
medline:
6
7
2021
entrez:
2
5
2020
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) is a chronic and devastating condition characterized by poor airflow and breath. Smoking and other environmental factors-caused inflammations triggered excessive autophagy of normal lung epithelial cells, eventually leading to impaired lung functions. Previous studies showed that ghrelin exhibited beneficial effects on patients with COPD. However, the mechanisms underlying this impact remained largely unknown. In this study, in vitro and in vivo models of COPD-associated inflammation were established, and we found that inflammation and autophagy were abonormally activated through nuclear factor kappa b (NF-κB) and activator protein-1 (AP-1) signaling pathways. Interestingly, ghrelin could inhibit the excessive inflammation pathways and autophagy induced by particle matter and/or cigarette extract in bronchial epithelial cells. Furthermore, NF-κB and AP-1 signaling were both inhibited while lung functions were significantly improved. Taken together, identification of downstream signaling of ghrelin in inflammation provided a new avenue in the treatment of COPD.
Substances chimiques
Ghrelin
0
NF-kappa B
0
Transcription Factor AP-1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
356-365Informations de copyright
© 2020 International Union of Biochemistry and Molecular Biology, Inc.
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