New Insights into the Implication of Mitochondrial Dysfunction in Tissue, Peripheral Blood Mononuclear Cells, and Platelets during Lung Diseases.
COPD
PBMCs
asthma
blood
lung diseases
mitochondria
oxidative stress
platelets
pulmonary arterial hypertension
pulmonary fibrosis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
26 Apr 2020
26 Apr 2020
Historique:
received:
29
02
2020
revised:
16
04
2020
accepted:
20
04
2020
entrez:
3
5
2020
pubmed:
3
5
2020
medline:
3
5
2020
Statut:
epublish
Résumé
Lung diseases such as chronic obstructive pulmonary disease, asthma, pulmonary arterial hypertension, or idiopathic pulmonary fibrosis are major causes of morbidity and mortality. Complex, their physiopathology is multifactorial and includes lung mitochondrial dysfunction and enhanced reactive oxygen species (ROS) release, which deserves increased attention. Further, and importantly, circulating blood cells (peripheral blood mononuclear cells-(PBMCs) and platelets) likely participate in these systemic diseases. This review presents the data published so far and shows that circulating blood cells mitochondrial oxidative capacity are likely to be reduced in chronic obstructive pulmonary disease (COPD), but enhanced in asthma and pulmonary arterial hypertension in a context of increased oxidative stress. Besides such PBMCs or platelets bioenergetics modifications, mitochondrial DNA (mtDNA) changes have also been observed in patients. These new insights open exciting challenges to determine their role as biomarkers or potential guide to a new therapeutic approach in lung diseases.
Identifiants
pubmed: 32357474
pii: jcm9051253
doi: 10.3390/jcm9051253
pmc: PMC7287602
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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