Anemia and Systemic Inflammation Rather than Arterial Circulatory Dysfunction Predict Decompensation of Liver Cirrhosis.
acute-on-chronic liver failure
ascites
decompensated liver cirrhosis
portal hypertension
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
26 Apr 2020
26 Apr 2020
Historique:
received:
29
03
2020
revised:
20
04
2020
accepted:
24
04
2020
entrez:
3
5
2020
pubmed:
3
5
2020
medline:
3
5
2020
Statut:
epublish
Résumé
While systemic inflammation is recognized as playing a central role in the pathogenesis of organ failures in patients with liver cirrhosis, less is known about its relevance in the development of classical hepatic decompensation. To characterize the relationship between systemic inflammation, hemodynamics, and anemia with decompensation of liver cirrhosis. This is a post-hoc analysis of a cohort study of outpatients with advanced liver fibrosis or cirrhosis. Analysis included 338 patients of whom 51 patients (15%) were hospitalized due to decompensation of liver cirrhosis during a median follow-up time of six months. In univariate analysis, active alcoholism ( Anemia and systemic inflammation, rather than arterial circulatory dysfunction, are strong and independent predictors of hepatic decompensation in outpatients with liver cirrhosis.
Sections du résumé
BACKGROUND
BACKGROUND
While systemic inflammation is recognized as playing a central role in the pathogenesis of organ failures in patients with liver cirrhosis, less is known about its relevance in the development of classical hepatic decompensation.
AIM
OBJECTIVE
To characterize the relationship between systemic inflammation, hemodynamics, and anemia with decompensation of liver cirrhosis.
METHODS
METHODS
This is a post-hoc analysis of a cohort study of outpatients with advanced liver fibrosis or cirrhosis.
RESULTS
RESULTS
Analysis included 338 patients of whom 51 patients (15%) were hospitalized due to decompensation of liver cirrhosis during a median follow-up time of six months. In univariate analysis, active alcoholism (
CONCLUSION
CONCLUSIONS
Anemia and systemic inflammation, rather than arterial circulatory dysfunction, are strong and independent predictors of hepatic decompensation in outpatients with liver cirrhosis.
Identifiants
pubmed: 32357568
pii: jcm9051263
doi: 10.3390/jcm9051263
pmc: PMC7287639
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : LA 2806/2-1 and LA 2806/5-1 to CML
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