Structure and Function of Human Matrix Metalloproteinases.
TIMP
collagen
matrix metalloproteinases
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
26 04 2020
26 04 2020
Historique:
received:
12
03
2020
revised:
15
04
2020
accepted:
21
04
2020
entrez:
3
5
2020
pubmed:
3
5
2020
medline:
17
3
2021
Statut:
epublish
Résumé
The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.
Identifiants
pubmed: 32357580
pii: cells9051076
doi: 10.3390/cells9051076
pmc: PMC7290392
pii:
doi:
Substances chimiques
Matrix Metalloproteinase Inhibitors
0
Collagen
9007-34-5
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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