Endothelin-1 signaling maintains glial progenitor proliferation in the postnatal subventricular zone.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
received:
08
05
2019
accepted:
06
04
2020
entrez:
3
5
2020
pubmed:
3
5
2020
medline:
4
8
2020
Statut:
epublish
Résumé
Signaling molecules that regulate neurodevelopmental processes in the early postnatal subventricular zone (SVZ) are critical for proper brain development yet remain poorly characterized. Here, we report that Endothelin-1 (ET-1), a molecular component of the postnatal SVZ, promotes radial glial cell maintenance and proliferation in an autocrine manner via Notch signaling. Loss of ET-1 signaling increases neurogenesis and reduces oligodendrocyte progenitor cell proliferation (OPC) in the developing SVZ, thereby altering cellular output of the stem cell niche. We also show that ET-1 is required for increased neural stem cell and OPC proliferation in the adult mouse SVZ following demyelination. Lastly, high levels of ET-1 in the SVZ of patients with Cathepsin A-related arteriopathy with strokes and leukoencephalopathy correlate with an increased number of SVZ OPCs, suggesting ET-1's role as a regulator of glial progenitor proliferation may be conserved in humans. ET-1 signaling therefore presents a potential new therapeutic target for promoting SVZ-mediated cellular repair.
Identifiants
pubmed: 32358570
doi: 10.1038/s41467-020-16028-8
pii: 10.1038/s41467-020-16028-8
pmc: PMC7195367
doi:
Substances chimiques
Endothelin-1
0
Receptors, Notch
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2138Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001876
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS090383
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090257
Pays : United States
Organisme : NINDS NIH HHS
ID : F32 NS098647
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001877
Pays : United States
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