Production aspects of testosterone by microbial biotransformation and future prospects.
Cholesterol
Fermentation
Microbial biotransformation
Testosterone
Journal
Steroids
ISSN: 1878-5867
Titre abrégé: Steroids
Pays: United States
ID NLM: 0404536
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
30
12
2019
revised:
30
03
2020
accepted:
24
04
2020
pubmed:
4
5
2020
medline:
10
2
2021
entrez:
4
5
2020
Statut:
ppublish
Résumé
In human males, TS plays a key role in maintaining health and sexual functioning. Cholesterol acts as a precursor molecule for its biosynthesis. The microbial biotransformation of cholesterol by numerous microbes like bacteria, fungi, yeasts, etc. has led to the synthesis of TS out of human body making it a great example for industrial steroid production due to its therapeutic properties. Biotransformation through microbes is more advantageous over chemical synthesis as it gives higher conversion rates, higher specificity; reaction goes under mild conditions like temperature and neutral pH, thus being an effective alternate to chemical route. Current review focuses on production aspects of TS by microbial biotransformation and its future prospects with recent advancement.
Identifiants
pubmed: 32360419
pii: S0039-128X(20)30076-3
doi: 10.1016/j.steroids.2020.108651
pii:
doi:
Substances chimiques
Testosterone
3XMK78S47O
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108651Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.