Design, synthesis, in vitro and in silico studies of 2, 3-diaryl benzofuran derivatives as antitubercular agents.
Anti-tubercular activity
Benzofuran
In-silico studies
Semi-synthetic derivatives
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
10
01
2020
revised:
12
03
2020
accepted:
20
03
2020
pubmed:
4
5
2020
medline:
2
3
2021
entrez:
4
5
2020
Statut:
ppublish
Résumé
As a part of our drug discovery program for anti-tubercular agents, a total of seventeen 2, 3-diaryl benzofuran hybrids were designed, synthesized and screened for their anti-tubercular potential against Mycobacterium tuberculosis H37Ra avirulent strain. Out of seventeen, four derivatives showed significant activity against M. tuberculosis H37Ra avirulent strain (ATCC 25177) with MIC value ranging from 12.5 to 50 µg/mL but out of four, one derivative (9E) was significantly active (MIC 12.5 μg/mL), which was further supported by the molecular docking energy (-8.4 kcal/mol) with respect to the first line anti-tubercular drug, isoniazid (-6.2 kcal/mol) on the target Polyketide Synthase-13. All the derivatives were also evaluated for their cytotoxicity against the normal lung cell line L-132 by the MTT assay and no toxicity was observed up to 27.4 µg/mL concentration. This report on the antitubercular potential of benzofuran derivatives may be of great help in anti-tubercular drug development.
Identifiants
pubmed: 32361184
pii: S0045-2068(20)30076-6
doi: 10.1016/j.bioorg.2020.103784
pii:
doi:
Substances chimiques
Antitubercular Agents
0
Benzofurans
0
benzofuran
LK6946W774
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103784Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.