Alendronate alleviates the symptoms of experimental autoimmune encephalomyelitis.

Alendronate / pharmacology Animals Anti-Inflammatory Agents / pharmacology Cell Proliferation / drug effects Cytokines / genetics Encephalomyelitis, Autoimmune, Experimental / drug therapy Female Mice, Inbred C57BL Multiple Sclerosis / drug therapy Nitric Oxide Synthase Type II / immunology Spinal Cord / drug effects T-Lymphocytes / drug effects
Alendronate Experimental autoimmune encephalomyelitis Inflammation Mevalonate cascade Multiple sclerosis

Journal

International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 04 02 2020
revised: 06 04 2020
accepted: 20 04 2020
pubmed: 4 5 2020
medline: 16 3 2021
entrez: 4 5 2020
Statut: ppublish

Résumé

Nitrogen-containing bisphosphonates, such as alendronate, have been widely used to treat osteoporosis because they may target multiple signals in the mevalonate cascade. The present study evaluated the therapeutic effects of alendronate on experimental autoimmune encephalomyelitis (EAE), which is a prototypical autoimmune disease model. EAE was induced in C57BL/6 mice by immunization with myelin oligodendrocyte glycoprotein (MOG)

Identifiants

DOI: 10.1016/j.intimp.2020.106534 PMID: 32361191
pubmed: 32361191
pii: S1567-5769(20)30312-X
doi: 10.1016/j.intimp.2020.106534
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Cytokines 0
Nitric Oxide Synthase Type II EC 1.14.13.39
Nos2 protein, mouse EC 1.14.13.39
Alendronate X1J18R4W8P

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106534

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Kyungsook Jung (K)

Functional Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Republic of Korea.

Jeongtae Kim (J)

Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Republic of Korea; Department of Anatomy, Kosin University College of Medicine, Busan 49267, Republic of Korea.

Ginnae Ahn (G)

Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, Republic of Korea.

Hiroshi Matsuda (H)

Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan; Laboratory of Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.

Tanaka Akane (T)

Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.

Meejung Ahn (M)

Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Republic of Korea; Department of Animal Science, College of Life Science, Sangji University, Wonju 26339, Republic of Korea.

Taekyun Shin (T)

Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Republic of Korea. Electronic address: shint@jejunu.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › Alendronate › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Eucaryotes › Animaux › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Nitric oxide synthase type II › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Alendronate alleviates the symptoms of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Alendronate alleviates the symptoms of...