Association between fetal growth restriction and maternal exposure to polybrominated diphenyl ethers.
Case-Control Studies
China
Colostrum
/ chemistry
Environmental Pollutants
/ toxicity
Female
Fetal Growth Retardation
/ chemically induced
Gas Chromatography-Mass Spectrometry
Halogenated Diphenyl Ethers
/ blood
Humans
Infant, Newborn
Maternal Exposure
Milk, Human
/ chemistry
Placenta
/ drug effects
Pregnancy
Colostrum
Fetal growth restriction
Gestational exposure
Lactational exposure
Maternal serum
Polybrominated diphenyl ethers
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
15 Jul 2020
15 Jul 2020
Historique:
received:
24
01
2020
revised:
30
03
2020
accepted:
09
04
2020
pubmed:
4
5
2020
medline:
16
12
2020
entrez:
4
5
2020
Statut:
ppublish
Résumé
Humans are exposed to polybrominated diphenyl ethers (PBDEs) via ingestion of food, dust inhalation, and dermal absorption. Exposure to PBDEs via the placenta and breast milk is a special and important pathway in infants. This nested case-control study aimed to investigate the levels of PBDEs in maternal serum and colostrum, and to assess the association between the occurrence of fetal growth restriction (FGR) and prenatal exposure to PBDEs. We recruited 293 mother-newborn pairs, including 98 FGR cases and 195 healthy controls in Wenzhou, China. Maternal serum and colostrum samples were collected during pregnancy and after delivery, respectively, and the levels of PBDEs were measured by gas chromatography-tandem mass spectrometry. The total levels of PBDEs in maternal serum and colostrum were found to be in equilibrium, but congener profiles of PBDEs in these matrices were different. Increased BDE-207, BDE-209, ∑BDE196-209 and ∑PBDEs levels in maternal serum and BDE-99, ∑BDE17-154 and ∑PBDEs levels in colostrum were correlated with decreased birth weight Z score. Increased concentrations of higher brominated BDEs in maternal serum (odds ratio (OR) = 1.010, 95%CI = 1.003-1.018) and low-to moderately brominated BDEs in colostrum (OR = 1.004, 95%CI = 1.000-1.009) were associated with increased risk of FGR, which showed an exposure-response relationship. In addition, infants with FGR were more exposed to PBDEs in colostrum after birth than healthy infants. Longitudinal birth cohort studies are needed to determine the prolonged effect of PBDEs exposure on the growth of FGR infants in the future.
Identifiants
pubmed: 32361490
pii: S0147-6513(20)30462-0
doi: 10.1016/j.ecoenv.2020.110623
pii:
doi:
Substances chimiques
2,2',4,4',5-brominated diphenyl ether
0
Environmental Pollutants
0
Halogenated Diphenyl Ethers
0
2,2',3,3',4,4',5,6,6'-nonabromodiphenyl ether
872OKM983V
decabromobiphenyl ether
N80BQ29A0H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110623Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest No competing interests exist.