Evidence from three cohort studies on the expression of MUC16 around the time of implantation suggests it is an inhibitor of implantation.
Adhesion molecules
Implantation
Inhibitor
Luminal epithelial
Mucin 16
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
09
01
2020
accepted:
27
03
2020
pubmed:
4
5
2020
medline:
14
1
2021
entrez:
4
5
2020
Statut:
ppublish
Résumé
To examine the expression of MUC16 in the endometrium peri-implantation period in three different cohort studies. This was a retrospective observational cohort study. A total of 245 participants were recruited in three separate cohort studies: (1) women with recurrent miscarriage (n = 50) and fertile controls (n = 29); (2) women who had high (n = 20) or normal (n = 20) progesterone on the day of hCG trigger in ovarian stimulation cycle for IVF; and (3) women who did (n = 95) or did not (n = 31) conceive following frozen embryo transfer in HRT cycles. All subjects had archived endometrial samples precisely taken on LH+7 in natural cycles, or hCG+6 in ovarian stimulation cycles, or P+5 in HRT cycles. The H-score (median, range) of MUC16 in the luminal epithelium and glandular epithelium was determined by using immunohistochemistry. The median (range) of H-score of MUC16 in the luminal epithelium (1) in women with recurrent pregnancy loss was 23.7 (0-300), which was significantly (P < 0.05) lower than that of 118.4 (7.7-300) in fertile controls; (2) in women with elevated progesterone on the day of hCG administration (147.8, 18.0-230.1), significantly (P < 0.05) higher than that of women with normal progesterone (61.0, 2.3-205.3); (3) in women who conceived (23.1, 0-250.3), significantly (P < 0.001) lower than that in women who did not conceive (58.4, 0-300). The expression of MUC16 in all three cohort studies is consistent with it being an inhibitor of implantation.
Identifiants
pubmed: 32361918
doi: 10.1007/s10815-020-01764-z
pii: 10.1007/s10815-020-01764-z
pmc: PMC7244680
doi:
Substances chimiques
CA-125 Antigen
0
MUC16 protein, human
0
Membrane Proteins
0
Progesterone
4G7DS2Q64Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1105-1115Subventions
Organisme : National Natural Science Foundation of China
ID : 81701514
Organisme : Chinese Medical Association clinical medical research special funding
ID : 17020560725
Organisme : Key Research and Development Program of Zhejiang Province
ID : 2017C03022
Références
Germeyer A, Savaris RF, Jauckus J, Lessey B. Endometrial beta3 integrin profile reflects endometrial receptivity defects in women with unexplained recurrent pregnancy loss. Reprod Biol Endocrinol. 2014;12:53.
doi: 10.1186/1477-7827-12-53
pubmed: 24950982
pmcid: 4074841
Xu B, Sun X, Li L, Wu L, Zhang A, Feng Y. Pinopodes, leukemia inhibitory factor, integrin-beta3, and mucin-1 expression in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss. Fertil Steril. 2012;98:389–95.
doi: 10.1016/j.fertnstert.2012.04.032
pubmed: 22698642
Jin XY, Zhao LJ, Luo DH, Liu L, Dai YD, Hu XX, et al. Pinopode score around the time of implantation is predictive of successful implantation following frozen embryo transfer in hormone replacement cycles. Hum Reprod. 2017;32:2394–403.
doi: 10.1093/humrep/dex312
pubmed: 29040606
Jiang R, Ding L, Zhou J, Huang C, Zhang Q, Jiang Y, et al. Enhanced HOXA10 sumoylation inhibits embryo implantation in women with recurrent implantation failure. Cell Death Dis. 2017;3:17057.
doi: 10.1038/cddiscovery.2017.57
Davidson LM, Coward K. Molecular mechanisms of membrane interaction at implantation. Birth Defects Res C Embryo Today. 2016;108:19–32.
doi: 10.1002/bdrc.21122
pubmed: 26969610
Thathiah A, Carson DD. Mucins and blastocyst attachment. Rev Endocr Metab Disord. 2002;3:87–96.
doi: 10.1023/A:1015446626671
pubmed: 12007285
DeSouza MM, Mani SK, Julian J, Carson DD. Reduction of mucin-1 expression during the receptive phase in the rat uterus. Biol Reprod. 1998;58:1503–7.
doi: 10.1095/biolreprod58.6.1503
pubmed: 9623612
Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update. 2006;12:731–46.
doi: 10.1093/humupd/dml004
pubmed: 16982667
Wu F, Chen X, Liu Y, Liang B, Xu H, Li TC, et al. Decreased MUC1 in endometrium is an independent receptivity marker in recurrent implantation failure during implantation window. Reprod Biol Endocrinol. 2018;16:60.
doi: 10.1186/s12958-018-0379-1
pubmed: 29929546
pmcid: 6013892
Brayman M, Thathiah A, Carson DD. MUC1: a multifunctional cell surface component of reproductive tissue epithelia. Reprod Biol Endocrinol. 2004;2:4.
doi: 10.1186/1477-7827-2-4
pubmed: 14711375
pmcid: 320498
Gipson IK, Blalock T, Tisdale A, Spurr-Michaud S, Allcorn S, Stavreus-Evers A, et al. MUC16 is lost from the uterodome (pinopode) surface of the receptive human endometrium: in vitro evidence that MUC16 is a barrier to trophoblast adherence. Biol Reprod. 2008;78:134–42.
doi: 10.1095/biolreprod.106.058347
pubmed: 17942799
Quenby S, Vince G, Farquharson R, Aplin J. Recurrent miscarriage: a defect in nature’s quality control? Hum Reprod. 2002;17:1959–63.
doi: 10.1093/humrep/17.8.1959
pubmed: 12151421
Liu L, Sailan S, Li T, Mariee N, Laird S, Jiang Z, et al. The effect of a high progesterone concentration before oocyte retrieval on the peri-implantation endometrium. Reprod BioMed Online. 2015;31:739–46.
doi: 10.1016/j.rbmo.2015.09.003
pubmed: 26515148
Liu L, Zhao L, Li TC, Zhu H, Lin X, Jin X, et al. Comparison of progesterone measurement on day of, and day after, HCG administration in IVF-embryo transfer cycles. Reprod BioMed Online. 2015;30:157–65.
doi: 10.1016/j.rbmo.2014.10.017
pubmed: 25530034
Bosch E, Labarta E, Crespo J, Simon C, Remohi J, Jenkins J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010;25:2092–100.
doi: 10.1093/humrep/deq125
pubmed: 20539042
Huang R, Fang C, Xu S, Yi Y, Liang X. Premature progesterone rise negatively correlated with live birth rate in IVF cycles with GnRH agonist: an analysis of 2,566 cycles. Fertil Steril. 2012;98:664–70 e2.
doi: 10.1016/j.fertnstert.2012.05.024
pubmed: 22704632
Stavreus-Evers A, Nikas G, Sahlin L, Eriksson H, Landgren BM. Formation of pinopodes in human endometrium is associated with the concentrations of progesterone and progesterone receptors. Fertil Steril. 2001;76:782–91.
doi: 10.1016/S0015-0282(01)01993-8
pubmed: 11591414
Xiong Y, Wang J, Liu L, Chen X, Xu H, Li TC, et al. Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification of endometrium in the peri-implantation period. Fertil Steril. 2017;108:269–76 e1.
doi: 10.1016/j.fertnstert.2017.06.004
pubmed: 28778281
Chen X, Mariee N, Jiang L, Liu Y, Wang CC, Li TC, et al. Measurement of uterine natural killer cell percentage in the periimplantation endometrium from fertile women and women with recurrent reproductive failure: establishment of a reference range. Am J Obstet Gynecol. 2017;217:680 e1-e6.
doi: 10.1016/j.ajog.2017.08.014
pubmed: 28935491
Weimar CH, Kavelaars A, Brosens JJ, Gellersen B, de Vreeden-Elbertse JM, Heijnen CJ, et al. Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos. PLoS One. 2012;7:e41424.
doi: 10.1371/journal.pone.0041424
pubmed: 22848492
pmcid: 3405140
Hey NA, Li TC, Devine PL, Graham RA, Saravelos H, Aplin JD. MUC1 in secretory phase endometrium: expression in precisely dated biopsies and flushings from normal and recurrent miscarriage patients. Hum Reprod. 1995;10:2655–62.
doi: 10.1093/oxfordjournals.humrep.a135762
pubmed: 8567787
Chervenak JL, Illsley NP. Episialin acts as an antiadhesive factor in an in vitro model of human endometrial-blastocyst attachment. Biol Reprod. 2000;63:294–300.
doi: 10.1095/biolreprod63.1.294
pubmed: 10859271
Meseguer M, Aplin JD, Caballero-Campo P, O'Connor JE, Martin JC, Remohi J, et al. Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biol Reprod. 2001;64:590–601.
doi: 10.1095/biolreprod64.2.590
pubmed: 11159362
Aplin JD, Meseguer M, Simon C, Ortiz ME, Croxatto H, Jones CJ. MUC1, glycans and the cell-surface barrier to embryo implantation. Biochem Soc Trans. 2001;29:153–6.
doi: 10.1042/bst0290153
pubmed: 11356144
Kaneko O, Gong L, Zhang J, Hansen JK, Hassan R, Lee B, et al. A binding domain on mesothelin for CA125/MUC16. J Biol Chem. 2009;284:3739–49.
doi: 10.1074/jbc.M806776200
pubmed: 19075018
pmcid: 2635045
Gipson IK, Spurr-Michaud S, Tisdale A, Menon BB. Comparison of the transmembrane mucins MUC1 and MUC16 in epithelial barrier function. PLoS One. 2014;9:e100393.
doi: 10.1371/journal.pone.0100393
pubmed: 24968021
pmcid: 4072602
Dalton CF, Laird SM, Estdale SE, Saravelos HG, Li TC. Endometrial protein PP14 and CA-125 in recurrent miscarriage patients; correlation with pregnancy outcome. Hum Reprod. 1998;13:3197–202.
doi: 10.1093/humrep/13.11.3197
pubmed: 9853880
Dalton CF, Laird SM, Serle E, Saravelos H, Warren MA, Li TC, et al. The measurement of CA 125 and placental protein 14 in uterine flushings in women with recurrent miscarriage; relation to endometrial morphology. Hum Reprod. 1995;10:2680–4.
doi: 10.1093/oxfordjournals.humrep.a135767
pubmed: 8567792
Dharmaraj N, Wang P, Carson DD. Cytokine and progesterone receptor interplay in the regulation of MUC1 gene expression. Mol Endocrinol. 2010;24:2253–66.
doi: 10.1210/me.2009-0448
pubmed: 20962044
pmcid: 2999481
Wang P, Dharmaraj N, Brayman MJ, Carson DD. Peroxisome proliferator-activated receptor gamma activation inhibits progesterone-stimulated human MUC1 expression. Mol Endocrinol. 2010;24:1368–79.
doi: 10.1210/me.2009-0221
pubmed: 20484415
pmcid: 2903911
Racicot KE, Wunsche V, Auerbach B, Aldo P, Silasi M, Mor G. Human chorionic gonadotropin enhances trophoblast-epithelial interaction in an in vitro model of human implantation. Reprod Sci. 2014;21:1274–80.
doi: 10.1177/1933719114522553
pubmed: 24520082
pmcid: 5933182
Ordi J, Creus M, Casamitjana R, Cardesa A, Vanrell JA, Balasch J. Endometrial pinopode and alphavbeta3 integrin expression is not impaired in infertile patients with endometriosis. J Assist Reprod Genet. 2003;20:465–73.
doi: 10.1023/B:JARG.0000006709.61216.6f
pubmed: 14714826
pmcid: 3455642
Creus M, Ordi J, Fabregues F, Casamitjana R, Carmona F, Cardesa A, et al. The effect of different hormone therapies on integrin expression and pinopode formation in the human endometrium: a controlled study. Hum Reprod. 2003;18:683–93.
doi: 10.1093/humrep/deg177
pubmed: 12660257
Perez BH, Gipson IK. Focus on molecules: human mucin MUC16. Exp Eye Res. 2008;87:400–1.
doi: 10.1016/j.exer.2007.12.008
pubmed: 18289532
pmcid: 2586928
Babic A, Cramer DW, Kelemen LE, Kobel M, Steed H, Webb PM, et al. Predictors of pretreatment CA125 at ovarian cancer diagnosis: a pooled analysis in the Ovarian Cancer Association Consortium. Cancer Causes Control. 2017;28:459–68.
doi: 10.1007/s10552-016-0841-3
pubmed: 28050675
pmcid: 5593071
Oliveira MAP, Raymundo TS, Soares LC, Pereira TRD, Demoro AVE. How to use CA-125 more effectively in the diagnosis of deep endometriosis. Biomed Res Int. 2017;2017:9857196.
pubmed: 28660213
pmcid: 5474266
Dharmaraj N, Chapela PJ, Morgado M, Hawkins SM, Lessey BA, Young SL, et al. Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis. Hum Reprod. 2014;29:1730–8.
doi: 10.1093/humrep/deu146
pubmed: 24939955
pmcid: 4093996
Constantinou PE, Morgado M, Carson DD. Transmembrane mucin expression and function in embryo implantation and placentation. Adv Anat Embryol Cell Biol. 2015;216:51–68.
doi: 10.1007/978-3-319-15856-3_4
pubmed: 26450494
Baalbergen A, Janssen JW, van der Weiden RM. CA-125 levels are related to the likelihood of pregnancy after in vitro fertilization and embryo transfer. Am J Reprod Immunol. 2000;43:21–4.
doi: 10.1111/j.8755-8920.2000.430104.x
pubmed: 10698036
Al Mohamady M, Fattah GA, Elkattan E, Bayoumy R, Hamed DA. Correlation of serum CA-125 and progesterone levels with ultrasound markers in the prediction of pregnancy outcome in threatened miscarriage. Int J Fertil Steril. 2016;9:506–11.
pubmed: 26985338