Novel Compound Heterozygous Variants of

ETHE1 chronic diarrhea elevated ethylmalonic acid ethylmalonic encephalopathy genetic sequencing

Journal

Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621

Informations de publication

Date de publication:
2020
Historique:
received: 02 08 2019
accepted: 23 03 2020
entrez: 5 5 2020
pubmed: 5 5 2020
medline: 5 5 2020
Statut: epublish

Résumé

Ethylmalonic encephalopathy (EE) is a very rare autosomal recessive metabolic disorder that primarily affects children. Less than one hundred EE patients have been diagnosed worldwide. The clinical manifestations include chronic diarrhea, petechiae, orthostatic acrocyanosis, psychomotor delay and regression, seizures, and hypotonia. The

Identifiants

pubmed: 32362910
doi: 10.3389/fgene.2020.00341
pmc: PMC7181787
doi:

Types de publication

Journal Article

Langues

eng

Pagination

341

Informations de copyright

Copyright © 2020 Chen, Han and Yao.

Références

Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Indian Pediatr. 2016 Oct 8;53(10):914-916
pubmed: 27771676
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018 Oct 10;35(5):694-698
pubmed: 30298498
Am J Hum Genet. 2004 Feb;74(2):239-52
pubmed: 14732903
Neuropediatrics. 2007 Apr;38(2):78-82
pubmed: 17712735
Lancet. 1991 Dec 14;338(8781):1522-3
pubmed: 1683940
PLoS One. 2012;7(10):e46688
pubmed: 23056405
Genome Res. 2002 Jun;12(6):996-1006
pubmed: 12045153
Front Physiol. 2012 Nov 28;3:448
pubmed: 23226130
Hum Mutat. 2003 Jun;21(6):577-81
pubmed: 12754702
Antioxid Redox Signal. 2011 Jul 15;15(2):353-62
pubmed: 20812865
Nat Med. 2009 Feb;15(2):200-5
pubmed: 19136963
Nature. 2016 Aug 17;536(7616):285-91
pubmed: 27535533
Hum Mol Genet. 2015 May 1;24(9):2458-69
pubmed: 25596185
J Med Genet. 2008 Jul;45(7):473-8
pubmed: 18593870
J Child Neurol. 2009 Aug;24(8):991-6
pubmed: 19289697
Genet Med. 2015 May;17(5):405-24
pubmed: 25741868
Brain. 2016 Apr;139(Pt 4):1045-51
pubmed: 26917598
Nat Methods. 2014 Apr;11(4):361-2
pubmed: 24681721
J Inherit Metab Dis. 2006 Oct;29(5):685
pubmed: 16906473
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Nucleic Acids Res. 2009 May;37(9):e67
pubmed: 19339519
Metab Brain Dis. 2015 Dec;30(6):1537-45
pubmed: 26194623
Curr Protoc Bioinformatics. 2013;43:11.10.1-11.10.33
pubmed: 25431634
Am J Med Genet A. 2019 Jun;179(6):1015-1019
pubmed: 30864297
Nat Rev Dis Primers. 2016 Oct 20;2:16080
pubmed: 27775730
Nat Med. 2010 Aug;16(8):869-71
pubmed: 20657580
Curr Protoc Hum Genet. 2013 Jan;Chapter 7:Unit7.20
pubmed: 23315928
Mol Med Rep. 2010 Mar-Apr;3(2):223-6
pubmed: 21472225

Auteurs

Xiaohong Chen (X)

Department of Endocrinology and Metabolism, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Lin Han (L)

Running Gene Inc., Beijing, China.

Hui Yao (H)

Department of Endocrinology and Metabolism, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Classifications MeSH