Clinical study of the tolerability of calcium carbonate-casein microcapsules as a dietary supplement in a group of postmenopausal women.
casein-functionalized calcium carbonate microcapsules
dietary calcium supplements
gastrointestinal adverse events
microencapsulated calcium carbonate
postmenopausal women
Journal
Drugs in context
ISSN: 1745-1981
Titre abrégé: Drugs Context
Pays: England
ID NLM: 101262187
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
01
2020
revised:
19
03
2020
accepted:
20
03
2020
entrez:
5
5
2020
pubmed:
5
5
2020
medline:
5
5
2020
Statut:
epublish
Résumé
Calcium is an essential macronutrient; however, currently supplements are often associated with gastrointestinal (GI) adverse events. The authors investigated the tolerability of a new delivery system for calcium supplementation, based on the functionalization of calcium carbonate (CaCO Around 208 postmenopausal women were enrolled and randomized 1:1:1:1 to one of the four calcium supplements, taken for 30 days: (1) microencapsulated CaCO The mean GSRS scores at baseline differed among the groups from 3.95 to 5.35 without statistical significance. After 1 month use of supplements, the group given microCaCO The microCaCO
Sections du résumé
BACKGROUND
BACKGROUND
Calcium is an essential macronutrient; however, currently supplements are often associated with gastrointestinal (GI) adverse events. The authors investigated the tolerability of a new delivery system for calcium supplementation, based on the functionalization of calcium carbonate (CaCO
METHODS
METHODS
Around 208 postmenopausal women were enrolled and randomized 1:1:1:1 to one of the four calcium supplements, taken for 30 days: (1) microencapsulated CaCO
RESULTS
RESULTS
The mean GSRS scores at baseline differed among the groups from 3.95 to 5.35 without statistical significance. After 1 month use of supplements, the group given microCaCO
CONCLUSIONS
CONCLUSIONS
The microCaCO
Identifiants
pubmed: 32362931
doi: 10.7573/dic.2020-1-4
pii: dic-2020-1-4
pmc: PMC7185908
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright © 2020 Palacios S, Ramirez M, Lilue M.
Déclaration de conflit d'intérêts
Disclosure and potential conflicts of interest: This work was supported by Nexentia S.A.S. The authors have no other conflict of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at https://www.drugsincontext.com/wp-content/uploads/2020/03/dic.2020-1-4-COI.pdf
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