Reactivation of Epstein-Barr Virus Hepatitis in T/Natural Killer (NK) Cells Mimicking Liver T/NK-Cell Lymphoma.
Chronic active EBV infection
EBV-associated hemophagocytic lymphohistiocytosis
Hepatitis
Steatohepatitis
T/NK-cell lymphoma
Journal
Gastroenterology research
ISSN: 1918-2805
Titre abrégé: Gastroenterology Res
Pays: Canada
ID NLM: 101519422
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
31
03
2020
accepted:
06
04
2020
entrez:
5
5
2020
pubmed:
5
5
2020
medline:
5
5
2020
Statut:
ppublish
Résumé
Diagnosis of Epstein-Barr virus (EBV)-associated hepatitis, chronic active EBV infection, and EBV-associated lymphoproliferative diseases, is always challenging due to the overlapping symptoms and lack of diagnostic criteria. We report such a case of a 40-year-old man with unremarkable past medical history. He presented with fever of unknown origin for 1 month with jaundice for 2 days. Physical exams were unremarkable with body temperature at 98.6 °F. His liver function tests were elevated with alanine transaminase (ALT) 559 U/L, aspartate transaminase (AST) 892 U/L, alkaline phosphatase 319 U/L and total bilirubin 4.4 mg/dL. Computed tomography of his chest, abdomen and pelvis did not show lymphadenopathy or hepatosplenomegaly. A liver biopsy showed moderately acute hepatitis with hemophagocytosis, positive Epstein-Barr virus encoding RNA (EBER)
Identifiants
pubmed: 32362967
doi: 10.14740/gr1283
pmc: PMC7188360
doi:
Types de publication
Case Reports
Langues
eng
Pagination
81-84Informations de copyright
Copyright 2020, Kwong et al.
Déclaration de conflit d'intérêts
All authors have approved this article and declare that they have no conflict of interest.
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