Factors Associated With Umbilical Cord Blood Collection Quality in Japan.
Hematopoietic stem cells
Japan
Single puncture
Umbilical cord blood collection
Umbilical cord blood quality
Journal
Journal of hematology
ISSN: 1927-1220
Titre abrégé: J Hematol
Pays: Canada
ID NLM: 101635099
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
04
04
2020
accepted:
13
04
2020
entrez:
5
5
2020
pubmed:
5
5
2020
medline:
5
5
2020
Statut:
ppublish
Résumé
Umbilical cord blood (UCB) has become an established alternative source of hematopoietic stem cells with marrow and postmobilization peripheral blood. The presence of a large amount of clots may lead to the deterioration of cord blood quality. To improve UCB quality as a source of hematopoietic stem cells in Japan, we examined factors associated with UCB collection methods from the viewpoint of eliminating the presence of clots. In August 2019, we requested the directors of 74 certified facilities to provide information on UCB collection methods in Japan. A total of 46 (62.2%) of them responded with valid information on a total of 2,892 UCB collections. In this study, collected UCB without clots macroscopically was evaluated as a high-quality UCB. The 2,891 UCB collections described during the study period were divided to those with (n = 760, 26.3%) and without clots (high quality; n = 2,131, 73.7%). Multivariate analysis revealed single puncture as a factor determining high-quality UCB collection (adjusted odds ratio (ORs): 1.80, 95% confidence interval (CI): 1.3 - 5.4, P = 0.01). Single puncture is an independent effective factor determining high-quality manual UCB collection in Japan.
Sections du résumé
BACKGROUND
BACKGROUND
Umbilical cord blood (UCB) has become an established alternative source of hematopoietic stem cells with marrow and postmobilization peripheral blood. The presence of a large amount of clots may lead to the deterioration of cord blood quality. To improve UCB quality as a source of hematopoietic stem cells in Japan, we examined factors associated with UCB collection methods from the viewpoint of eliminating the presence of clots.
METHODS
METHODS
In August 2019, we requested the directors of 74 certified facilities to provide information on UCB collection methods in Japan. A total of 46 (62.2%) of them responded with valid information on a total of 2,892 UCB collections. In this study, collected UCB without clots macroscopically was evaluated as a high-quality UCB.
RESULTS
RESULTS
The 2,891 UCB collections described during the study period were divided to those with (n = 760, 26.3%) and without clots (high quality; n = 2,131, 73.7%). Multivariate analysis revealed single puncture as a factor determining high-quality UCB collection (adjusted odds ratio (ORs): 1.80, 95% confidence interval (CI): 1.3 - 5.4, P = 0.01).
CONCLUSIONS
CONCLUSIONS
Single puncture is an independent effective factor determining high-quality manual UCB collection in Japan.
Identifiants
pubmed: 32362979
doi: 10.14740/jh628
pmc: PMC7188375
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9-12Informations de copyright
Copyright 2020, Suzuki et al.
Déclaration de conflit d'intérêts
None to declare.
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