Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2.
COVID-19
IgG
IgM
diagnostics
rapid test
sars-CoV-2
Journal
Infection ecology & epidemiology
ISSN: 2000-8686
Titre abrégé: Infect Ecol Epidemiol
Pays: United States
ID NLM: 101579795
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
04
2020
accepted:
07
04
2020
entrez:
5
5
2020
pubmed:
5
5
2020
medline:
5
5
2020
Statut:
epublish
Résumé
COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.
Identifiants
pubmed: 32363011
doi: 10.1080/20008686.2020.1754538
pii: 1754538
pmc: PMC7178815
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1754538Informations de copyright
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
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