Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19).

COVID-19 Hydroxychloroquine SARS-CoV-2 chloroquine clinical trials coronavirus

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 08 04 2020
accepted: 13 04 2020
entrez: 5 5 2020
pubmed: 5 5 2020
medline: 5 5 2020
Statut: epublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical trials, uncontrolled case series, and public figure endorsements. While there is a growing body of scientific data, there is also concern for harm, particularly QTc prolongation and cardiac arrhythmias. Here, we perform a rapid narrative review and discuss the strengths and limitations of existing

Identifiants

pubmed: 32363212
doi: 10.1093/ofid/ofaa130
pii: ofaa130
pmc: PMC7184359
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

ofaa130

Subventions

Organisme : NIAID NIH HHS
ID : K23 AI138851
Pays : United States
Organisme : NIAID NIH HHS
ID : T35 AI118620
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007347
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI055433
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW009345
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH121220
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI134262
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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Auteurs

Katelyn A Pastick (KA)

Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Elizabeth C Okafor (EC)

Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Fan Wang (F)

Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota.

Sarah M Lofgren (SM)

Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Caleb P Skipper (CP)

Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Melanie R Nicol (MR)

Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota.

Matthew F Pullen (MF)

Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Radha Rajasingham (R)

Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Emily G McDonald (EG)

Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Canada.

Todd C Lee (TC)

Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Canada.

Ilan S Schwartz (IS)

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta.

Lauren E Kelly (LE)

Department of Pediatrics and Child Health, Department of Pharmacology, University of Manitoba, Winnipeg, Canada.

Sylvain A Lother (SA)

Department of Medicine, Sections of Critical Care and Infectious Diseases, University of Manitoba, Winnipeg, Canada.

Oriol Mitjà (O)

Fight AIDS and Inf Dis Foundation, Hospital Germans Trias i Pujol, Barcelona, Spain.

Emili Letang (E)

Department of Infectious Diseases, Hospital del Mar/Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
ISGlobal, Barcelona Institute for Global Health, Universitat de Barcelona, Barcelona, Spain.

Mahsa Abassi (M)

Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

David R Boulware (DR)

Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Classifications MeSH