High-Efficiency Biocatalytic Conversion of Thebaine to Codeine.


Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
28 Apr 2020
Historique:
received: 21 01 2020
accepted: 23 03 2020
entrez: 5 5 2020
pubmed: 5 5 2020
medline: 5 5 2020
Statut: epublish

Résumé

An enzymatic biosynthesis approach is described for codeine, the most widely used medicinal opiate, providing a more environmentally sustainable alternative to current chemical conversion, with yields and productivity compatible with industrial production.

Identifiants

pubmed: 32363285
doi: 10.1021/acsomega.0c00282
pmc: PMC7191831
doi:

Types de publication

Journal Article

Langues

eng

Pagination

9339-9347

Informations de copyright

Copyright © 2020 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Xu Li (X)

Department of Chemical Engineering, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.
The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.

Konrad Krysiak-Baltyn (K)

Department of Chemical Engineering, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.
The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.

Luke Richards (L)

Department of Chemical Engineering, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.
The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.

Ailsa Jarrold (A)

Sun Pharmaceutical Industries Australia Pty Ltd., Princes Highway, Port Fairy, Victoria 3281, Australia.

Geoffrey W Stevens (GW)

Department of Chemical Engineering, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.

Tim Bowser (T)

Impact Science Consulting, Unit 2/52 Swanston Street, Heidelberg Heights, Melbourne, Victoria 3081, Australia.

Robert E Speight (RE)

School of Biology and Environmental Science, Queensland University of Technology, Brisbane, Queensland 4000, Australia.

Sally L Gras (SL)

Department of Chemical Engineering, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.
The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.

Classifications MeSH