Inclusion Complexation between α-Cyclodextrin and Oligo(ethylene glycol) Methyl Ether Methacrylate.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
28 Apr 2020
28 Apr 2020
Historique:
received:
19
02
2020
accepted:
01
04
2020
entrez:
5
5
2020
pubmed:
5
5
2020
medline:
5
5
2020
Statut:
epublish
Résumé
The preparation of inclusion complexes based on α-cyclodextrin (α-CD) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA) was investigated aiming to reveal complexation particularities and thermodynamic and kinetic aspects as a function of the oligomer architecture. Small-angle X-ray scattering and isothermal titration calorimetry measurements revealed that oligomer molecular weight controls both the kinetics and thermodynamics of inclusion. Unlike linear ethylene glycol polymers, OEGMA groups possess a methacrylate group, which seems to act as a stopper, affecting their mode of complexation. Nuclear magnetic resonance spectra and relaxation measurements support the fact that methacrylate groups lie outside the α-CD ring and that a full sequential complexation of the oligomer ethylene oxide groups is not observed. These results allied to the temperature sensitivity of these oligomers and enable possible routes for chemical modifications and design of new stimuli-responsive materials.
Identifiants
pubmed: 32363304
doi: 10.1021/acsomega.0c00741
pmc: PMC7191851
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9517-9528Informations de copyright
Copyright © 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Drug Discov Today. 2012 Jun;17(11-12):623-9
pubmed: 22326233
Langmuir. 2018 Sep 11;34(36):10591-10602
pubmed: 30095271
Biomacromolecules. 2016 Feb 8;17(2):649-60
pubmed: 26741744
Science. 2018 Mar 16;359(6381):1239-1243
pubmed: 29590071
Nat Chem. 2018 Jun;10(6):625-630
pubmed: 29713030
Chem Rev. 1998 Jul 30;98(5):1755-1786
pubmed: 11848948
Adv Drug Deliv Rev. 2008 Jun 10;60(9):1000-17
pubmed: 18413280
Biochim Biophys Acta. 2016 May;1860(5):999-1016
pubmed: 26459003
Polymers (Basel). 2018 May 23;10(6):
pubmed: 30966610
Acc Chem Res. 2001 Jun;34(6):456-64
pubmed: 11412082
Micron. 2008 Jul;39(5):495-516
pubmed: 17706427
Food Res Int. 2019 Nov;125:108634
pubmed: 31554109
Nat Commun. 2017 Jun 20;8:15856
pubmed: 28631756
J Phys Chem B. 2008 Jan 31;112(4):1071-81
pubmed: 18181596
Angew Chem Int Ed Engl. 2014 Oct 13;53(42):11158-71
pubmed: 25070083
J Phys Chem B. 2012 Oct 4;116(39):11953-8
pubmed: 22957770
Langmuir. 2013 Apr 16;29(15):4664-9
pubmed: 23510502
Chem Rev. 1998 Jul 30;98(5):1787-1802
pubmed: 11848949
Langmuir. 2008 Sep 16;24(18):10005-10
pubmed: 18712892
J Phys Chem B. 2007 May 31;111(21):5911-20
pubmed: 17488116
Angew Chem Int Ed Engl. 2005 Sep 5;44(35):5658-61
pubmed: 16052643
Langmuir. 2018 Jan 16;34(2):709-714
pubmed: 28945378
Chem Rev. 1998 Jul 30;98(5):1875-1918
pubmed: 11848952
J Mater Chem B. 2013 Dec 7;1(45):6235-6244
pubmed: 32261696
Int J Pharm. 2010 Mar 15;387(1-2):199-208
pubmed: 19963052
Angew Chem Int Ed Engl. 2016 Sep 19;55(39):11979-83
pubmed: 27558980