Determinants of accelerated metabolomic and epigenetic aging in a UK cohort.
DNA methylation
accelerated aging
affective mood disorders
metabolomics
molecular biology of aging
risk factors
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
19
09
2019
revised:
19
12
2019
accepted:
02
03
2020
pubmed:
5
5
2020
medline:
14
7
2021
entrez:
5
5
2020
Statut:
ppublish
Résumé
Markers of biological aging have potential utility in primary care and public health. We developed a model of age based on untargeted metabolic profiling across multiple platforms, including nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry in urine and serum, within a large sample (N = 2,239) from the UK Airwave cohort. We validated a subset of model predictors in a Finnish cohort including repeat measurements from 2,144 individuals. We investigated the determinants of accelerated aging, including lifestyle and psychological risk factors for premature mortality. The metabolomic age model was well correlated with chronological age (mean r = .86 across independent test sets). Increased metabolomic age acceleration (mAA) was associated after false discovery rate (FDR) correction with overweight/obesity, diabetes, heavy alcohol use and depression. DNA methylation age acceleration measures were uncorrelated with mAA. Increased DNA methylation phenotypic age acceleration (N = 1,110) was associated after FDR correction with heavy alcohol use, hypertension and low income. In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks.
Identifiants
pubmed: 32363781
doi: 10.1111/acel.13149
pmc: PMC7294785
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13149Subventions
Organisme : Medical Research Council
ID : MR/L01341X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S03532X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S03658X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L01632X/1
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Références
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Aging Cell. 2018 Feb;17(1):
pubmed: 29044988
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
PLoS Comput Biol. 2013;9(7):e1003123
pubmed: 23861661
BMJ. 2018 Mar 23;360:k1046
pubmed: 29572376
Br J Psychiatry. 2002 Aug;181:158-62
pubmed: 12151288
Am J Epidemiol. 2018 Mar 1;187(3):529-538
pubmed: 29020168
Aging (Albany NY). 2019 Apr 14;11(7):2045-2070
pubmed: 31009935
Endocrinol Metab Clin North Am. 2013 Jun;42(2):319-32
pubmed: 23702404
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4104-10
pubmed: 26150497
Aging Cell. 2012 Dec;11(6):960-7
pubmed: 22834969
Mech Ageing Dev. 2015 Nov;151:2-12
pubmed: 25818235
Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4252-9
pubmed: 27036001
Am J Epidemiol. 2018 Jun 1;187(6):1220-1230
pubmed: 29149257
J Stat Softw. 2010;33(1):1-22
pubmed: 20808728
Ageing Res Rev. 2013 Mar;12(2):509-19
pubmed: 23333817
Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):210-215
pubmed: 28087676
Circ Cardiovasc Genet. 2015 Feb;8(1):192-206
pubmed: 25691689
Sci Rep. 2017 Nov 24;7(1):16266
pubmed: 29176660
J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1370-1376
pubmed: 28958059
Curr Psychiatry Rep. 2017 Aug 29;19(10):75
pubmed: 28852965
EBioMedicine. 2017 Jul;21:29-36
pubmed: 28396265
Nat Commun. 2017 Jul 27;8:15842
pubmed: 28748955
J Affect Disord. 2018 Jul;234:117-123
pubmed: 29525352
Mol Cell. 2013 Jan 24;49(2):359-367
pubmed: 23177740
CNS Spectr. 2014 Aug;19(4):293-304
pubmed: 24103843
J Proteome Res. 2016 Dec 2;15(12):4188-4194
pubmed: 27628670
Environ Res. 2014 Oct;134:280-5
pubmed: 25194498
J Proteome Res. 2016 Feb 5;15(2):400-10
pubmed: 26652958
Paediatr Perinat Epidemiol. 1988 Jan;2(1):59-88
pubmed: 2976931
Nat Commun. 2015 Oct 22;6:8570
pubmed: 26490707
Aging Cell. 2020 Jun;19(6):e13149
pubmed: 32363781
Genome Biol. 2016 Aug 11;17(1):171
pubmed: 27511193
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
pubmed: 6880820
Mutat Res. 2001 Apr 18;475(1-2):37-44
pubmed: 11295152
Int J Obes (Lond). 2016 May;40(5):773-8
pubmed: 26607038
Age Ageing. 2015 Jul;44(4):713-7
pubmed: 25983277
Nat Med. 2006 Apr;12(4):446-51
pubmed: 16565722
Aging (Albany NY). 2016 Sep 28;8(9):1844-1865
pubmed: 27690265
Cell. 2016 Aug 11;166(4):802-821
pubmed: 27518560
Nucleic Acids Res. 2018 Jul 2;46(W1):W486-W494
pubmed: 29762782
Sci Transl Med. 2015 Apr 29;7(285):285ra62
pubmed: 25925681
PLoS One. 2017 Aug 16;12(8):e0183228
pubmed: 28813537
Nat Commun. 2014 Aug 21;5:4708
pubmed: 25144627
Circ Res. 2018 Sep 14;123(7):740-744
pubmed: 30355074
BMC Bioinformatics. 2007 Jul 02;8:234
pubmed: 17605789
J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):667-74
pubmed: 23213031
Genome Biol. 2013;14(10):R115
pubmed: 24138928
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941