Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug.

Administration, Cutaneous Drug Delivery Systems Gelatin Needles Water beta-Cyclodextrins
gelatin methacryloyl microneedles transdermal delivery water insoluble drugs β-cyclodextrin

Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
06 2020
Historique:
received: 01 04 2020
pubmed: 5 5 2020
medline: 15 5 2021
entrez: 5 5 2020
Statut: ppublish

Résumé

Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-β-CD MN arrays patch.

Identifiants

DOI: 10.1002/adhm.202000527 PMID: 32364331 PMC: PMC7462883
pubmed: 32364331
doi: 10.1002/adhm.202000527
pmc: PMC7462883
mid: NIHMS1621654
doi:

Substances chimiques

beta-Cyclodextrins 0
Water 059QF0KO0R
Gelatin 9000-70-8

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2000527

Subventions

Organisme : NIBIB NIH HHS
ID : R01 EB024403
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126831
Pays : United States

Informations de copyright

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Xingwu Zhou (X)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Zhimin Luo (Z)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China.

Avijit Baidya (A)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Han-Jun Kim (HJ)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Canran Wang (C)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Xing Jiang (X)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Moyuan Qu (M)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.

Jixiang Zhu (J)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.

Li Ren (L)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Fereshteh Vajhadin (F)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Chemistry, Yazd University, Yazd, 89195, Iran.

Peyton Tebon (P)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Niyuan Zhang (N)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Yumeng Xue (Y)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Yudi Feng (Y)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Chengbin Xue (C)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Yi Chen (Y)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

KangJu Lee (K)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Junmin Lee (J)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Shiming Zhang (S)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Chun Xu (C)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia.

Nureddin Ashammakhi (N)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Samad Ahadian (S)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.

Mehmet Remzi Dokmeci (MR)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.

Zhen Gu (Z)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Wujin Sun (W)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Ali Khademhosseini (A)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics, California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
ORCID: 0000-0001-6322-8852

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Administration par voie cutanée › Biodegradable β-Cyclodextrin Conjugated...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Biodegradable β-Cyclodextrin Conjugated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Gélatine › Biodegradable β-Cyclodextrin Conjugated...
questionsmedicales.fr › Équipement et fournitures › Aiguilles › Biodegradable β-Cyclodextrin Conjugated...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Biodegradable β-Cyclodextrin Conjugated...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Amidon › Dextrine › Cyclodextrines › Cyclodextrines bêta › Biodegradable β-Cyclodextrin Conjugated...