Interferon-λ Receptor Expression: Novel Reporter Mouse Reveals Within- and Cross-Tissue Heterogeneity.

Animals Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Receptors, Interferon / genetics Interferon gamma Receptor
epithelial cells interferon-λ mucosal immunity reporter mouse

Journal

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
ISSN: 1557-7465
Titre abrégé: J Interferon Cytokine Res
Pays: United States
ID NLM: 9507088

Informations de publication

Date de publication:
06 2020
Historique:
pubmed: 5 5 2020
medline: 17 7 2021
entrez: 5 5 2020
Statut: ppublish

Résumé

Interferon-λ (IFN-λ) plays an important role in mucosal immunity, but reliable information regarding the expression of the IFN-λ receptor in individual cells is still missing. One reason for this knowledge gap is the lack of antibodies that specifically recognize the unique IFNLR1 subunit of the dimeric IFN-λ receptor complex. In this study, we investigated whether a reporter mouse carrying a bacterial β-galactosidase gene inserted into the

Identifiants

DOI: 10.1089/jir.2019.0265 PMID: 32364818
pubmed: 32364818
doi: 10.1089/jir.2019.0265
doi:

Substances chimiques

IFNLR1 protein, mouse 0
Receptors, Interferon 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

292-300

Auteurs

Julian Linden (J)

Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.

Daniel Schnepf (D)

Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.

Marilena Wischnewski (M)

Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.

Liang Ye (L)

Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.

Jana Gawron (J)

Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.

Annette Ohnemus (A)

Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.

Christin Friedrich (C)

Institute of Medical Microbiology and Hygiene, Medical Center University of Freiburg, Freiburg, Germany.
Würzburg Institute of Systems Immunology, University of Würzburg, Würzburg, Germany.

Georg Gasteiger (G)

Institute of Medical Microbiology and Hygiene, Medical Center University of Freiburg, Freiburg, Germany.
Würzburg Institute of Systems Immunology, University of Würzburg, Würzburg, Germany.

Peter Staeheli (P)

Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
Medical Faculty, University of Freiburg, Freiburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Interferon-λ Receptor Expression: Novel...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Interferon-λ Receptor Expression: Novel...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Interferon-λ Receptor Expression: Novel...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Interferon-λ Receptor Expression: Novel...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Interferon-λ Receptor Expression: Novel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteur interféron › Interferon-λ Receptor Expression: Novel...