Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD.
Age-related Macular Degeneration (AMD)
HNG
Humanin
MDPs
MOTS-c
RPE
SHLPs
mitochondria
mitochondrial-derived peptides
neuroprotection
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
29 04 2020
29 04 2020
Historique:
received:
02
02
2020
revised:
21
04
2020
accepted:
23
04
2020
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.
Identifiants
pubmed: 32365540
pii: cells9051102
doi: 10.3390/cells9051102
pmc: PMC7290668
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Neurosci Lett. 2002 May 24;324(3):227-31
pubmed: 12009529
Brain Res. 2008 Aug 28;1227:12-8
pubmed: 18590709
J Mol Endocrinol. 2013 Jan 11;50(1):R11-9
pubmed: 23239898
Biochim Biophys Acta. 1999 Feb 9;1410(2):103-23
pubmed: 10076021
PLoS One. 2016 Oct 26;11(10):e0165150
pubmed: 27783653
Free Radic Biol Med. 2016 Nov;100:182-187
pubmed: 27216708
Neural Regen Res. 2013 Sep 25;8(27):2573-80
pubmed: 25206568
J Biol Chem. 2005 Apr 22;280(16):15825-35
pubmed: 15661735
Life Sci. 2005 Oct 28;77(24):3092-104
pubmed: 16005025
Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H393-7
pubmed: 23220334
Oncotarget. 2018 Feb 3;9(13):10832-10833
pubmed: 29541379
Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2848-55
pubmed: 18344451
Apoptosis. 2015 Apr;20(4):551-61
pubmed: 25666707
Eye Brain. 2010;2:99-116
pubmed: 23226947
Clin Dermatol. 2016 Mar-Apr;34(2):276-85
pubmed: 26903189
Aging Cell. 2015 Dec;14(6):921-3
pubmed: 26289118
Physiol Rep. 2019 Jul;7(13):e14171
pubmed: 31293078
Sci Rep. 2014 Feb 13;4:4089
pubmed: 24522485
J Inherit Metab Dis. 1992;15(4):439-47
pubmed: 1528004
Oxid Med Cell Longev. 2017;2017:1675230
pubmed: 28814984
Cold Spring Harb Perspect Biol. 2012 Dec 01;4(12):
pubmed: 23143808
PLoS One. 2009 Jul 22;4(7):e6334
pubmed: 19623253
Arch Ophthalmol. 2011 Jan;129(1):75-80
pubmed: 21220632
Mol Cell. 2018 Mar 1;69(5):757-772.e7
pubmed: 29499132
Sci Rep. 2017 Aug 10;7(1):7802
pubmed: 28798389
Biomed Res Int. 2014;2014:238463
pubmed: 24818134
Nanomedicine. 2020 Feb;24:102111
pubmed: 31655204
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13042-7
pubmed: 14561895
Nat Commun. 2018 Apr 10;9(1):1364
pubmed: 29636475
Endocrinology. 2013 Oct;154(10):3739-44
pubmed: 23836030
Br J Ophthalmol. 2017 Jul;101(7):970-975
pubmed: 27913442
Life Sci. 2012 Sep 4;91(5-6):199-206
pubmed: 22820173
Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1238-53
pubmed: 26990160
Peptides. 2003 Apr;24(4):585-95
pubmed: 12860203
Protein Pept Lett. 2015;22(10):869-76
pubmed: 26216267
Proc Natl Acad Sci U S A. 2001 May 22;98(11):6336-41
pubmed: 11371646
Cell Death Dis. 2017 Jul 20;8(7):e2951
pubmed: 28726777
J Cell Physiol. 2006 Aug;208(2):373-85
pubmed: 16619233
Oncotarget. 2016 Jul 26;7(30):46899-46912
pubmed: 27384491
Metabolomics. 2019 Jun 6;15(6):88
pubmed: 31172328
Biology (Basel). 2019 May 11;8(2):
pubmed: 31083549
Invest Ophthalmol Vis Sci. 2006 Mar;47(3):815-22
pubmed: 16505012
Fertil Steril. 2010 Dec;94(7):2888-90
pubmed: 20542501
Int J Mol Sci. 2019 Sep 09;20(18):
pubmed: 31505887
Annu Rev Immunol. 1997;15:797-819
pubmed: 9143707
Br J Dermatol. 2013 Jul;169 Suppl 2:1-8
pubmed: 23786614
Nature. 2003 May 22;423(6938):456-61
pubmed: 12732850
Cell Metab. 2018 Sep 4;28(3):516-524.e7
pubmed: 29983246
Sci Rep. 2018 Oct 11;8(1):15175
pubmed: 30310092
Aging Cell. 2014 Oct;13(5):958-61
pubmed: 25040290
Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1940-8
pubmed: 20651283
PLoS One. 2012;7(2):e31065
pubmed: 22328926
Aging (Albany NY). 2018 Jun 10;10(6):1239-1256
pubmed: 29886458
Aging (Albany NY). 2016 Apr;8(4):796-809
pubmed: 27070352
Cardiovasc Res. 2010 Nov 1;88(2):360-6
pubmed: 20562421
Atherosclerosis. 2011 Nov;219(1):65-73
pubmed: 21763658
Mol Biol Cell. 2009 Jun;20(12):2864-73
pubmed: 19386761
Endocrinology. 2015 Dec;156(12):4511-21
pubmed: 26384090
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5470-9
pubmed: 20505194