Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt
DALDA
DAMGO
KGOP01
[Dmt1]DALDA
binding
molecular docking
mu opioid receptor
opioid peptides and peptidomimetics
structure-activity relationships
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
29 Apr 2020
29 Apr 2020
Historique:
received:
08
04
2020
revised:
25
04
2020
accepted:
27
04
2020
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
11
2
2021
Statut:
epublish
Résumé
The mu opioid receptor (MOR) is the primary target for analgesia of endogenous opioid peptides, alkaloids, synthetic small molecules with diverse scaffolds, and peptidomimetics. Peptide-based opioids are viewed as potential analgesics with reduced side effects and have received constant scientific interest over the years. This study focuses on three potent peptide and peptidomimetic MOR agonists, DALDA, [Dmt
Identifiants
pubmed: 32365707
pii: molecules25092087
doi: 10.3390/molecules25092087
pmc: PMC7248707
pii:
doi:
Substances chimiques
Oligopeptides
0
Peptides
0
Receptors, Opioid, mu
0
tyrosyl-arginyl-phenylalanyl-lysinamide
118476-85-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund FWF
ID : I 2463
Pays : Austria
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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