The Application of a Low-temperature Physical Plasma Device Operating Under Atmospheric Pressure Leads to the Production of Toxic NO


Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
May 2020
Historique:
received: 09 03 2020
revised: 06 04 2020
accepted: 08 04 2020
entrez: 6 5 2020
pubmed: 6 5 2020
medline: 15 5 2020
Statut: ppublish

Résumé

Physical plasma is a mixture of reactive particles and electromagnetic radiation. Due to the antimicrobial, immunomodulatory, anti-inflammatory, wound-healing promoting, and antineoplastic effects of body tempered physical plasma under atmospheric pressure (cold atmospheric plasma: CAP), CAP therapy is increasingly becoming the focus of surgical and oncological disciplines. However, when applied in practice, a potential emission of harmful noxae such as toxic nitrogen oxides must be taken into account, which was investigated in the following study. MiniJet-R Ar CAP device was characterized with respect to NO The operation of MiniJet-R led to the formation of NO Although no limit values were exceeded in the present study, the emission of high-energy UVC radiation and toxic NO

Sections du résumé

BACKGROUND BACKGROUND
Physical plasma is a mixture of reactive particles and electromagnetic radiation. Due to the antimicrobial, immunomodulatory, anti-inflammatory, wound-healing promoting, and antineoplastic effects of body tempered physical plasma under atmospheric pressure (cold atmospheric plasma: CAP), CAP therapy is increasingly becoming the focus of surgical and oncological disciplines. However, when applied in practice, a potential emission of harmful noxae such as toxic nitrogen oxides must be taken into account, which was investigated in the following study.
MATERIALS AND METHODS METHODS
MiniJet-R Ar CAP device was characterized with respect to NO
RESULTS RESULTS
The operation of MiniJet-R led to the formation of NO
CONCLUSION CONCLUSIONS
Although no limit values were exceeded in the present study, the emission of high-energy UVC radiation and toxic NO

Identifiants

pubmed: 32366404
pii: 40/5/2591
doi: 10.21873/anticanres.14230
doi:

Substances chimiques

Plasma Gases 0
Nitric Oxide 31C4KY9ESH
Nitrogen Dioxide S7G510RUBH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2591-2599

Informations de copyright

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Karsten Kletschkus (K)

Plasma Oncology Laboratory, Department of Urology, University Medicine Greifswald, Greifswald, Germany.

Lyubomir Haralambiev (L)

Department of Trauma, Reconstructive Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany.
Department of Trauma and Orthopaedic Surgery, BG Klinikum Unfallkrankenhaus Berlin GmbH, Berlin, Germany.

Andreas Nitsch (A)

Department of Trauma, Reconstructive Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany.

Felix Pfister (F)

Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.

Gerd Klinkmann (G)

Department of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, Rostock, Germany.

Axel Kramer (A)

Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany.

Sander Bekeschus (S)

ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP Greifswald), Greifswald, Germany.

Alexander Mustea (A)

Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.

Matthias B Stope (MB)

Plasma Oncology Laboratory, Department of Urology, University Medicine Greifswald, Greifswald, Germany matthias.stope@ukbonn.de.
Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.

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Classifications MeSH