Cryptic Acute Promyelocytic Leukemia (APL) Presenting as Seizures in an Adolescent.
Journal
Annals of clinical and laboratory science
ISSN: 1550-8080
Titre abrégé: Ann Clin Lab Sci
Pays: United States
ID NLM: 0410247
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
6
5
2020
pubmed:
6
5
2020
medline:
4
2
2021
Statut:
ppublish
Résumé
There are approximately 800 new cases of acute promyelocytic leukemia (APL) in the United States every year. APL is rarely observed in pediatric populations, and accounts for less than 5-10% of all pediatric cases of acute myeloid leukemia (AML). APL typically presents with symptoms related to the pancytopenia such as fatigue due to anemia, bleeding and bruising secondary to thrombocytopenia, and infections attributed to a lack of functioning leukocytes. The presentation of APL in the central nervous system (CNS) is a rare phenomenon. In addition, APL has a dismal prognosis when found in the CNS. In this case study, we describe a unique presentation of pediatric APL with cryptic insertion of the promyelocytic leukemia (PML)-retinoic acid receptor-alpha (RARA) fusion protein with a surprisingly excellent recovery.
Substances chimiques
Oncogene Proteins, Fusion
0
promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
270-273Informations de copyright
© 2020 by the Association of Clinical Scientists, Inc.