The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.
Animals
Cell Movement
/ genetics
Dishevelled Proteins
/ genetics
Guanine Nucleotide Exchange Factors
/ genetics
HEK293 Cells
Humans
Neural Crest
/ cytology
Phenotype
Plasmids
/ genetics
Protein Binding
/ genetics
Protein Domains
Protein Serine-Threonine Kinases
/ genetics
Signal Transduction
/ genetics
Transfection
Xenopus Proteins
/ genetics
Xenopus laevis
/ embryology
rac1 GTP-Binding Protein
/ metabolism
rhoA GTP-Binding Protein
/ metabolism
Cadherin-11
Dishevelled
GEF Trio
Neural crest cell migration
Rho GTPases
Xenopus
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
22 05 2020
22 05 2020
Historique:
received:
13
11
2019
accepted:
08
04
2020
pubmed:
6
5
2020
medline:
22
12
2020
entrez:
6
5
2020
Statut:
epublish
Résumé
Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay signals, as it features distinct catalytic domains to activate Rho GTPases. Here, we show that Trio is required for
Identifiants
pubmed: 32366678
pii: dev.186338
doi: 10.1242/dev.186338
pii:
doi:
Substances chimiques
DVL1 protein, Xenopus
0
DVL2 protein, human
0
Dishevelled Proteins
0
Dvl2 protein, Xenopus
0
Guanine Nucleotide Exchange Factors
0
Xenopus Proteins
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
TRIO protein, human
EC 2.7.11.1
rac1 GTP-Binding Protein
EC 3.6.5.2
rhoA GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.