Quercetin Blocks Ebola Virus Infection by Counteracting the VP24 Interferon-Inhibitory Function.
EBOV
Ebola virus
IFN signaling
VP24
drug development
flavonoids
luciferase assay
quercetin
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
23 06 2020
23 06 2020
Historique:
received:
18
03
2020
accepted:
28
04
2020
pubmed:
6
5
2020
medline:
22
6
2021
entrez:
6
5
2020
Statut:
epublish
Résumé
Ebola virus (EBOV) is among the most devastating pathogens causing fatal hemorrhagic fever in humans. The epidemics from 2013 to 2016 resulted in more than 11,000 deaths, and another outbreak is currently ongoing. Since there is no FDA-approved drug so far to fight EBOV infection, there is an urgent need to focus on drug discovery. Considering the tight correlation between the high EBOV virulence and its ability to suppress the type I interferon (IFN-I) system, identifying molecules targeting viral protein VP24, one of the main virulence determinants blocking the IFN response, is a promising novel anti-EBOV therapy approach. Hence, in the effort to find novel EBOV inhibitors, a screening of a small set of flavonoids was performed; it showed that quercetin and wogonin can suppress the VP24 effect on IFN-I signaling inhibition. The mechanism of action of the most active compound, quercetin, showing a half-maximal inhibitory concentration (IC
Identifiants
pubmed: 32366711
pii: AAC.00530-20
doi: 10.1128/AAC.00530-20
pmc: PMC7318047
pii:
doi:
Substances chimiques
Antiviral Agents
0
VP24 protein, Ebola virus
0
Viral Proteins
0
Interferons
9008-11-1
Quercetin
9IKM0I5T1E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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