Ex vivo pulsed dendritic cell vaccination against cancer.
DC vaccination
T-cell activation
cancer antigens
cancer immunotherapy
dendritic cells
mRNA-pulsed DC vaccines
tumor microenvironment
Journal
Acta pharmacologica Sinica
ISSN: 1745-7254
Titre abrégé: Acta Pharmacol Sin
Pays: United States
ID NLM: 100956087
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
15
12
2019
accepted:
30
03
2020
pubmed:
6
5
2020
medline:
2
2
2021
entrez:
6
5
2020
Statut:
ppublish
Résumé
As the most powerful antigen-presenting cell type, dendritic cells (DCs) can induce potent antigen-specific immune responses in vivo, hence becoming optimal cell population for vaccination purposes. DCs can be derived ex vivo in quantity and manipulated extensively to be endowed with adequate immune-stimulating capacity. After pulsing with cancer antigens in various ways, the matured DCs are administrated back into the patient. DCs home to lymphoid organs to present antigens to and activate specific lymphocytes that react to a given cancer. Ex vivo pulsed DC vaccines have been vigorously investigated for decades, registering encouraging results in relevant immunotherapeutic clinical trials, while facing some solid challenges. With more details in DC biology understood, new theory proposed, and novel technology introduced (featuring recently emerged mRNA vaccine technology), it is becoming increasingly likely that ex vivo pulsed DC vaccine will fulfill its potential in cancer immunotherapy.
Identifiants
pubmed: 32366940
doi: 10.1038/s41401-020-0415-5
pii: 10.1038/s41401-020-0415-5
pmc: PMC7470877
doi:
Substances chimiques
Cancer Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
959-969Références
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