SARS-CoV-2 can induce brain and spine demyelinating lesions.
COVID-19
Demyelinating lesions
Immune response
Neuro-COVID
SARS-CoV-2
Seizures
Journal
Acta neurochirurgica
ISSN: 0942-0940
Titre abrégé: Acta Neurochir (Wien)
Pays: Austria
ID NLM: 0151000
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
17
04
2020
accepted:
23
04
2020
pubmed:
6
5
2020
medline:
6
5
2020
entrez:
6
5
2020
Statut:
ppublish
Résumé
SARS-CoV-2 can attack the central nervous system in the early stages of infection. Headache, anosmia, and dysgeusia are common symptoms. Disturbance of consciousness and seizures can occur as complications in case of severe COVID-19. We described the case of a COVID-19 patient admitted for interstitial pneumonia and seizures. MRI showed newly diagnosed demyelinating lesions. High-dose steroid treatment allowed neurological and respiratory recovery. We speculated a delayed immune response induced by SARS-CoV-2. The virus may lead to a SIRS-like immune disorder or play a role of infective trigger. Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries.
Identifiants
pubmed: 32367205
doi: 10.1007/s00701-020-04374-x
pii: 10.1007/s00701-020-04374-x
pmc: PMC7197630
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1491-1494Commentaires et corrections
Type : CommentIn
Références
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Viruses. 2019 Dec 20;12(1):
pubmed: 31861926
Zhonghua Shao Shang Za Zhi. 2020 Jun 20;36(6):471-475
pubmed: 32114747
J Exp Med. 2005 Aug 1;202(3):415-24
pubmed: 16043521
ACS Chem Neurosci. 2020 Apr 1;11(7):995-998
pubmed: 32167747
Autoimmun Rev. 2020 May;19(5):102524
pubmed: 32220633
Di Yi Jun Yi Da Xue Xue Bao. 2003 Nov;23(11):1125-7
pubmed: 14625166
Int J Infect Dis. 2020 May;94:55-58
pubmed: 32251791
Int J Infect Dis. 2014 Dec;29:301-6
pubmed: 25303830
J Clin Neurol. 2017 Jul;13(3):227-233
pubmed: 28748673
Lancet Neurol. 2020 May;19(5):383-384
pubmed: 32246917
Acta Neurol Taiwan. 2005 Sep;14(3):113-9
pubmed: 16252612
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
Nat Immunol. 2017 Feb;18(2):132-141
pubmed: 28092376
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
N Engl J Med. 2020 Jun 4;382(23):2268-2270
pubmed: 32294339
Brain Behav Immun. 2020 Jul;87:128-129
pubmed: 32387343
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Brain Behav Immun. 2020 Aug;88:945-946
pubmed: 32283294
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508