Defining the phenotype, pathogenesis and treatment of Crohn's disease associated spondyloarthritis.
Crohn’s disease
Microbiome
Spondyloarthritis
Journal
Journal of gastroenterology
ISSN: 1435-5922
Titre abrégé: J Gastroenterol
Pays: Japan
ID NLM: 9430794
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
03
04
2020
accepted:
14
04
2020
pubmed:
6
5
2020
medline:
14
10
2021
entrez:
6
5
2020
Statut:
ppublish
Résumé
Peripheral and axial spondyloarthritis are the most common extra-intestinal manifestations reported in patients with Crohn's disease. Despite the frequency of Crohn's disease associated spondyloarthritis, clinical diagnostic tools are variably applied in these cohorts and further characterization with validated spondyloarthritis disease activity indexes are needed. In addition, the pathogenesis of Crohn's disease associated spondyloarthritis is not well understood. Evidence of shared genetic, cellular, and microbial mechanisms underlying both Crohn's disease and spondyloarthritis highlight the potential for a distinct clinicopathologic entity. Existing treatment paradigms for Crohn's disease associated spondyloarthritis focus on symptom control and management of luminal inflammation. A better understanding of the underlying pathogenic mechanisms in Crohn's disease associated spondyloarthritis and the link between the gut microbiome and systemic immunity will help pave the way for more targeted and effective therapies. This review highlights recent work that has provided a framework for clinical characterization and pathogenesis of Crohn's disease associated spondyloarthritis and helps identify critical gaps that will help shape treatment paradigms.
Identifiants
pubmed: 32367294
doi: 10.1007/s00535-020-01692-w
pii: 10.1007/s00535-020-01692-w
pmc: PMC7297835
mid: NIHMS1600653
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
667-678Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK114252
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120985
Pays : United States
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