Administration of Bifidobacterium bifidum CGMCC 15068 modulates gut microbiota and metabolome in azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis-associated colon cancer (CAC) in mice.

Animals Azoxymethane / toxicity Bifidobacterium bifidum / physiology Carcinogenesis / drug effects Colitis-Associated Neoplasms / chemically induced Dextran Sulfate / toxicity Disease Models, Animal Feces / chemistry Gastrointestinal Microbiome / drug effects Male Metabolome / drug effects Mice Mice, Inbred C57BL Probiotics / administration & dosage
Bifidobacterium bifidum CGMCC 15068 Colorectal cancer Gut microbiota Metabolome

Journal

Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 08 12 2019
accepted: 09 04 2020
revised: 31 03 2020
pubmed: 6 5 2020
medline: 27 1 2021
entrez: 6 5 2020
Statut: ppublish

Résumé

The gut microbiota plays an important role in colorectal cancer (CRC), and the use of probiotics might be a promising intervention method. The aim of our study was to investigate the beneficial effect of Bifidobacterium bifidum CGMCC 15068 on an azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis-associated CRC (CAC) mouse model. CAC was induced by an intra-peritoneal injection of AOM (10 mg/kg) and three 7-day cycles of 2% DSS in drinking water with a 14-day recovery period between two consecutive DSS administrations. B. bifidum CGMCC 15068 (3 × 10

Identifiants

DOI: 10.1007/s00253-020-10621-z PMID: 32367312
pubmed: 32367312
doi: 10.1007/s00253-020-10621-z
pii: 10.1007/s00253-020-10621-z
doi:

Substances chimiques

Dextran Sulfate 9042-14-2
Azoxymethane MO0N1J0SEN

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5915-5928

Subventions

Organisme : National Natural Science Foundation of China
ID : 81790631
Organisme : National Natural Science Foundation of China
ID : 81570512

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Auteurs

Qing Wang (Q)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Kaicen Wang (K)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Wenrui Wu (W)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Longxian Lv (L)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Xiaoyuan Bian (X)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Liya Yang (L)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Qiangqiang Wang (Q)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Yating Li (Y)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Jianzhong Ye (J)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Daiqiong Fang (D)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Jingjing Wu (J)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Xianwan Jiang (X)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Jiaojiao Xie (J)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Yanmeng Lu (Y)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China.

Lanjuan Li (L)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China. ljli@zju.edu.cn.
Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China. ljli@zju.edu.cn.
National Clinical Research Center for Infectious Diseases, Hangzhou, 310003, China. ljli@zju.edu.cn.

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Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Composés chimiques organiques › Composés azoïques › Oxyde de diméthyl-diazène › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes irréguliers à Gram positif › Actinobacteria › Bifidobacterium › Bifidobacterium bifidum › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Néoplasmes associés aux colites › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Dextrane › Sulfate dextran › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Métabolisme › Métabolome › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Administration of Bifidobacterium bifidum...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Probiotiques › Administration of Bifidobacterium bifidum...